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COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study
The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146232/ https://www.ncbi.nlm.nih.gov/pubmed/35632505 http://dx.doi.org/10.3390/vaccines10050749 |
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author | de Freitas Paganoti, Cristiane Alkmin da Costa, Rafaela Papageorghiou, Aris T. da Silva Costa, Fabrício Quintana, Silvana Maria Graziela de Godoi, Luciana Adriana Jiménez Monroy, Nátaly Sacramento Rodrigues, Agatha Pulcineli Vieira Francisco, Rossana |
author_facet | de Freitas Paganoti, Cristiane Alkmin da Costa, Rafaela Papageorghiou, Aris T. da Silva Costa, Fabrício Quintana, Silvana Maria Graziela de Godoi, Luciana Adriana Jiménez Monroy, Nátaly Sacramento Rodrigues, Agatha Pulcineli Vieira Francisco, Rossana |
author_sort | de Freitas Paganoti, Cristiane |
collection | PubMed |
description | The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS. |
format | Online Article Text |
id | pubmed-9146232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91462322022-05-29 COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study de Freitas Paganoti, Cristiane Alkmin da Costa, Rafaela Papageorghiou, Aris T. da Silva Costa, Fabrício Quintana, Silvana Maria Graziela de Godoi, Luciana Adriana Jiménez Monroy, Nátaly Sacramento Rodrigues, Agatha Pulcineli Vieira Francisco, Rossana Vaccines (Basel) Article The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS. MDPI 2022-05-10 /pmc/articles/PMC9146232/ /pubmed/35632505 http://dx.doi.org/10.3390/vaccines10050749 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Freitas Paganoti, Cristiane Alkmin da Costa, Rafaela Papageorghiou, Aris T. da Silva Costa, Fabrício Quintana, Silvana Maria Graziela de Godoi, Luciana Adriana Jiménez Monroy, Nátaly Sacramento Rodrigues, Agatha Pulcineli Vieira Francisco, Rossana COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title | COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title_full | COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title_fullStr | COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title_full_unstemmed | COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title_short | COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study |
title_sort | covid-19 vaccines confer protection in hospitalized pregnant and postpartum women with severe covid-19: a retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146232/ https://www.ncbi.nlm.nih.gov/pubmed/35632505 http://dx.doi.org/10.3390/vaccines10050749 |
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