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Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides

To cope with the rising food demand, modern agriculture practices are based on the indiscriminate use of agrochemicals. Although this strategy leads to a temporary solution, it also severely damages the environment, representing a risk to human health. A sustainable alternative to agrochemicals is t...

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Detalles Bibliográficos
Autores principales: Soriano, Gabriele, Petrillo, Claudia, Masi, Marco, Bouafiane, Mabrouka, Khelil, Aminata, Tuzi, Angela, Isticato, Rachele, Fernández-Aparicio, Mónica, Cimmino, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146260/
https://www.ncbi.nlm.nih.gov/pubmed/35622558
http://dx.doi.org/10.3390/toxins14050311
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author Soriano, Gabriele
Petrillo, Claudia
Masi, Marco
Bouafiane, Mabrouka
Khelil, Aminata
Tuzi, Angela
Isticato, Rachele
Fernández-Aparicio, Mónica
Cimmino, Alessio
author_facet Soriano, Gabriele
Petrillo, Claudia
Masi, Marco
Bouafiane, Mabrouka
Khelil, Aminata
Tuzi, Angela
Isticato, Rachele
Fernández-Aparicio, Mónica
Cimmino, Alessio
author_sort Soriano, Gabriele
collection PubMed
description To cope with the rising food demand, modern agriculture practices are based on the indiscriminate use of agrochemicals. Although this strategy leads to a temporary solution, it also severely damages the environment, representing a risk to human health. A sustainable alternative to agrochemicals is the use of plant metabolites and plant-based pesticides, known to have minimal environmental impact compared to synthetic pesticides. Retama raetam is a shrub growing in Algeria’s desert areas, where it is commonly used in traditional medicine because of its antiseptic and antipyretic properties. Furthermore, its allelopathic features can be exploited to effectively control phytopathogens in the agricultural field. In this study, six compounds belonging to isoflavones and flavones subgroups have been isolated from the R. raetam dichloromethane extract and identified using spectroscopic and optical methods as alpinumisoflavone, hydroxyalpinumisoflavone, laburnetin, licoflavone C, retamasin B, and ephedroidin. Their antifungal activity was evaluated against the fungal phytopathogen Stemphylium vesicarium using a growth inhibition bioassay on PDA plates. Interestingly, the flavonoid laburnetin, the most active metabolite, displayed an inhibitory activity comparable to that exerted by the synthetic fungicide pentachloronitrobenzene, in a ten-fold lower concentration. The allelopathic activity of R. raetam metabolites against parasitic weeds was also investigated using two independent parasitic weed bioassays to discover potential activities on either suicidal stimulation or radicle growth inhibition of broomrapes. In this latter bioassay, ephedroidin strongly inhibited the growth of Orobanche cumana radicles and, therefore, can be proposed as a natural herbicide.
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spelling pubmed-91462602022-05-29 Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides Soriano, Gabriele Petrillo, Claudia Masi, Marco Bouafiane, Mabrouka Khelil, Aminata Tuzi, Angela Isticato, Rachele Fernández-Aparicio, Mónica Cimmino, Alessio Toxins (Basel) Article To cope with the rising food demand, modern agriculture practices are based on the indiscriminate use of agrochemicals. Although this strategy leads to a temporary solution, it also severely damages the environment, representing a risk to human health. A sustainable alternative to agrochemicals is the use of plant metabolites and plant-based pesticides, known to have minimal environmental impact compared to synthetic pesticides. Retama raetam is a shrub growing in Algeria’s desert areas, where it is commonly used in traditional medicine because of its antiseptic and antipyretic properties. Furthermore, its allelopathic features can be exploited to effectively control phytopathogens in the agricultural field. In this study, six compounds belonging to isoflavones and flavones subgroups have been isolated from the R. raetam dichloromethane extract and identified using spectroscopic and optical methods as alpinumisoflavone, hydroxyalpinumisoflavone, laburnetin, licoflavone C, retamasin B, and ephedroidin. Their antifungal activity was evaluated against the fungal phytopathogen Stemphylium vesicarium using a growth inhibition bioassay on PDA plates. Interestingly, the flavonoid laburnetin, the most active metabolite, displayed an inhibitory activity comparable to that exerted by the synthetic fungicide pentachloronitrobenzene, in a ten-fold lower concentration. The allelopathic activity of R. raetam metabolites against parasitic weeds was also investigated using two independent parasitic weed bioassays to discover potential activities on either suicidal stimulation or radicle growth inhibition of broomrapes. In this latter bioassay, ephedroidin strongly inhibited the growth of Orobanche cumana radicles and, therefore, can be proposed as a natural herbicide. MDPI 2022-04-28 /pmc/articles/PMC9146260/ /pubmed/35622558 http://dx.doi.org/10.3390/toxins14050311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soriano, Gabriele
Petrillo, Claudia
Masi, Marco
Bouafiane, Mabrouka
Khelil, Aminata
Tuzi, Angela
Isticato, Rachele
Fernández-Aparicio, Mónica
Cimmino, Alessio
Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title_full Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title_fullStr Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title_full_unstemmed Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title_short Specialized Metabolites from the Allelopathic Plant Retama raetam as Potential Biopesticides
title_sort specialized metabolites from the allelopathic plant retama raetam as potential biopesticides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146260/
https://www.ncbi.nlm.nih.gov/pubmed/35622558
http://dx.doi.org/10.3390/toxins14050311
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