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Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential
Plant-based medicines have received a lot of attention in recent years. Such medicines have been employed to treat medical conditions since ancient times, and in those times only the observed symptoms were used to determine dose accuracy, dose efficacy, and therapy. Rather than novel formulations, t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146286/ https://www.ncbi.nlm.nih.gov/pubmed/35631677 http://dx.doi.org/10.3390/pharmaceutics14051091 |
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author | Kumari, Sapna Goyal, Anju Sönmez Gürer, Eda Algın Yapar, Evren Garg, Madhukar Sood, Meenakshi Sindhu, Rakesh K. |
author_facet | Kumari, Sapna Goyal, Anju Sönmez Gürer, Eda Algın Yapar, Evren Garg, Madhukar Sood, Meenakshi Sindhu, Rakesh K. |
author_sort | Kumari, Sapna |
collection | PubMed |
description | Plant-based medicines have received a lot of attention in recent years. Such medicines have been employed to treat medical conditions since ancient times, and in those times only the observed symptoms were used to determine dose accuracy, dose efficacy, and therapy. Rather than novel formulations, the current research work on plant-based medicines has mostly concentrated on medicinal active phytoconstituents. In the past recent decades, however, researchers have made significant progress in developing “new drug delivery systems” (NDDS) to enhance therapeutic efficacy and reduce unwanted effects of bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, and other innovative therapeutic formulations have all been created using bioactive compounds and plant extracts. The novel formulations can improve solubility, therapeutic efficacy, bioavailability, stability, tissue distribution, protection from physical and chemical damage, and prolonged and targeted administration, to name a few. The current study summarizes existing research and the development of new formulations, with a focus on herbal bioactive components. |
format | Online Article Text |
id | pubmed-9146286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91462862022-05-29 Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential Kumari, Sapna Goyal, Anju Sönmez Gürer, Eda Algın Yapar, Evren Garg, Madhukar Sood, Meenakshi Sindhu, Rakesh K. Pharmaceutics Review Plant-based medicines have received a lot of attention in recent years. Such medicines have been employed to treat medical conditions since ancient times, and in those times only the observed symptoms were used to determine dose accuracy, dose efficacy, and therapy. Rather than novel formulations, the current research work on plant-based medicines has mostly concentrated on medicinal active phytoconstituents. In the past recent decades, however, researchers have made significant progress in developing “new drug delivery systems” (NDDS) to enhance therapeutic efficacy and reduce unwanted effects of bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, and other innovative therapeutic formulations have all been created using bioactive compounds and plant extracts. The novel formulations can improve solubility, therapeutic efficacy, bioavailability, stability, tissue distribution, protection from physical and chemical damage, and prolonged and targeted administration, to name a few. The current study summarizes existing research and the development of new formulations, with a focus on herbal bioactive components. MDPI 2022-05-19 /pmc/articles/PMC9146286/ /pubmed/35631677 http://dx.doi.org/10.3390/pharmaceutics14051091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kumari, Sapna Goyal, Anju Sönmez Gürer, Eda Algın Yapar, Evren Garg, Madhukar Sood, Meenakshi Sindhu, Rakesh K. Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title | Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title_full | Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title_fullStr | Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title_full_unstemmed | Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title_short | Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential |
title_sort | bioactive loaded novel nano-formulations for targeted drug delivery and their therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146286/ https://www.ncbi.nlm.nih.gov/pubmed/35631677 http://dx.doi.org/10.3390/pharmaceutics14051091 |
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