Cargando…

Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial

There are limited studies on neuroprotection from repeated subconcussive head impacts (RSHI) following docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) supplementation in contact sports athletes. We performed a randomized, placebo-controlled, double-blinded, parallel-group design trial to de...

Descripción completa

Detalles Bibliográficos
Autores principales: Mullins, Veronica A., Graham, Sarah, Cummings, Danielle, Wood, Alva, Ovando, Vanessa, Skulas-Ray, Ann C., Polian, Dennis, Wang, Yiwei, Hernandez, Gerson D., Lopez, Claudia M., Raikes, Adam C., Brinton, Roberta D., Chilton, Floyd H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146417/
https://www.ncbi.nlm.nih.gov/pubmed/35631280
http://dx.doi.org/10.3390/nu14102139
_version_ 1784716558521597952
author Mullins, Veronica A.
Graham, Sarah
Cummings, Danielle
Wood, Alva
Ovando, Vanessa
Skulas-Ray, Ann C.
Polian, Dennis
Wang, Yiwei
Hernandez, Gerson D.
Lopez, Claudia M.
Raikes, Adam C.
Brinton, Roberta D.
Chilton, Floyd H.
author_facet Mullins, Veronica A.
Graham, Sarah
Cummings, Danielle
Wood, Alva
Ovando, Vanessa
Skulas-Ray, Ann C.
Polian, Dennis
Wang, Yiwei
Hernandez, Gerson D.
Lopez, Claudia M.
Raikes, Adam C.
Brinton, Roberta D.
Chilton, Floyd H.
author_sort Mullins, Veronica A.
collection PubMed
description There are limited studies on neuroprotection from repeated subconcussive head impacts (RSHI) following docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) supplementation in contact sports athletes. We performed a randomized, placebo-controlled, double-blinded, parallel-group design trial to determine the impact of 26 weeks of DHA+EPA supplementation (n = 12) vs. placebo (high-oleic safflower oil) (n = 17) on serum concentrations of neurofilament light (NfL), a biomarker of axonal injury, and inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a)) in National Collegiate Athletic Association Division I American football athletes. DHA+EPA supplementation increased (p < 0.01) plasma DHA and EPA concentrations throughout the treatment period. NfL concentrations increased from baseline to week 26 in both groups (treatment (<0.001); placebo (p < 0.05)), with starting players (vs. non-starters) showing significant higher circulating concentrations at week 26 (p < 0.01). Fish oil (DHA+EPA) supplementation did not mitigate the adverse effects of RSHI, as measured by NfL levels; however, participants with the highest plasma DHA+EPA concentrations tended to have lower NfL levels. DHA+EPA supplementation had no effects on inflammatory cytokine levels at any of the timepoints tested. These findings emphasize the need for effective strategies to protect American football participants from the effects of RSHI.
format Online
Article
Text
id pubmed-9146417
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91464172022-05-29 Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial Mullins, Veronica A. Graham, Sarah Cummings, Danielle Wood, Alva Ovando, Vanessa Skulas-Ray, Ann C. Polian, Dennis Wang, Yiwei Hernandez, Gerson D. Lopez, Claudia M. Raikes, Adam C. Brinton, Roberta D. Chilton, Floyd H. Nutrients Article There are limited studies on neuroprotection from repeated subconcussive head impacts (RSHI) following docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) supplementation in contact sports athletes. We performed a randomized, placebo-controlled, double-blinded, parallel-group design trial to determine the impact of 26 weeks of DHA+EPA supplementation (n = 12) vs. placebo (high-oleic safflower oil) (n = 17) on serum concentrations of neurofilament light (NfL), a biomarker of axonal injury, and inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a)) in National Collegiate Athletic Association Division I American football athletes. DHA+EPA supplementation increased (p < 0.01) plasma DHA and EPA concentrations throughout the treatment period. NfL concentrations increased from baseline to week 26 in both groups (treatment (<0.001); placebo (p < 0.05)), with starting players (vs. non-starters) showing significant higher circulating concentrations at week 26 (p < 0.01). Fish oil (DHA+EPA) supplementation did not mitigate the adverse effects of RSHI, as measured by NfL levels; however, participants with the highest plasma DHA+EPA concentrations tended to have lower NfL levels. DHA+EPA supplementation had no effects on inflammatory cytokine levels at any of the timepoints tested. These findings emphasize the need for effective strategies to protect American football participants from the effects of RSHI. MDPI 2022-05-20 /pmc/articles/PMC9146417/ /pubmed/35631280 http://dx.doi.org/10.3390/nu14102139 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mullins, Veronica A.
Graham, Sarah
Cummings, Danielle
Wood, Alva
Ovando, Vanessa
Skulas-Ray, Ann C.
Polian, Dennis
Wang, Yiwei
Hernandez, Gerson D.
Lopez, Claudia M.
Raikes, Adam C.
Brinton, Roberta D.
Chilton, Floyd H.
Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title_full Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title_fullStr Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title_full_unstemmed Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title_short Effects of Fish Oil on Biomarkers of Axonal Injury and Inflammation in American Football Players: A Placebo-Controlled Randomized Controlled Trial
title_sort effects of fish oil on biomarkers of axonal injury and inflammation in american football players: a placebo-controlled randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146417/
https://www.ncbi.nlm.nih.gov/pubmed/35631280
http://dx.doi.org/10.3390/nu14102139
work_keys_str_mv AT mullinsveronicaa effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT grahamsarah effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT cummingsdanielle effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT woodalva effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT ovandovanessa effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT skulasrayannc effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT poliandennis effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT wangyiwei effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT hernandezgersond effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT lopezclaudiam effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT raikesadamc effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT brintonrobertad effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial
AT chiltonfloydh effectsoffishoilonbiomarkersofaxonalinjuryandinflammationinamericanfootballplayersaplacebocontrolledrandomizedcontrolledtrial