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Hepatitis B Virus-Associated Hepatocellular Carcinoma
Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can prog...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146458/ https://www.ncbi.nlm.nih.gov/pubmed/35632728 http://dx.doi.org/10.3390/v14050986 |
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author | Rizzo, Giacomo Emanuele Maria Cabibbo, Giuseppe Craxì, Antonio |
author_facet | Rizzo, Giacomo Emanuele Maria Cabibbo, Giuseppe Craxì, Antonio |
author_sort | Rizzo, Giacomo Emanuele Maria |
collection | PubMed |
description | Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can progressively lead to liver cirrhosis, which is an independent risk factor for HCC. Complications as liver decompensation or HCC impact the survival of HBV patients and concurrent HDV infection worsens the disease. The available data provide evidence that HBV infection is associated with the risk of developing HCC with or without an underlying liver cirrhosis, due to various direct and indirect mechanisms promoting hepatocarcinogenesis. The molecular profile of HBV-HCC is extensively and continuously under study, and it is the result of altered molecular pathways, which modify the microenvironment and lead to DNA damage. HBV produces the protein HBx, which has a central role in the oncogenetic process. Furthermore, the molecular profile of HBV-HCC was recently discerned from that of HDV-HCC, despite the obligatory dependence of HDV on HBV. Proper management of the underlying HBV-related liver disease is fundamental, including HCC surveillance, viral suppression, and application of adequate predictive models. When HBV-HCC occurs, liver function and HCC characteristics guide the physician among treatment strategies but always considering the viral etiology in the treatment choice. |
format | Online Article Text |
id | pubmed-9146458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91464582022-05-29 Hepatitis B Virus-Associated Hepatocellular Carcinoma Rizzo, Giacomo Emanuele Maria Cabibbo, Giuseppe Craxì, Antonio Viruses Review Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can progressively lead to liver cirrhosis, which is an independent risk factor for HCC. Complications as liver decompensation or HCC impact the survival of HBV patients and concurrent HDV infection worsens the disease. The available data provide evidence that HBV infection is associated with the risk of developing HCC with or without an underlying liver cirrhosis, due to various direct and indirect mechanisms promoting hepatocarcinogenesis. The molecular profile of HBV-HCC is extensively and continuously under study, and it is the result of altered molecular pathways, which modify the microenvironment and lead to DNA damage. HBV produces the protein HBx, which has a central role in the oncogenetic process. Furthermore, the molecular profile of HBV-HCC was recently discerned from that of HDV-HCC, despite the obligatory dependence of HDV on HBV. Proper management of the underlying HBV-related liver disease is fundamental, including HCC surveillance, viral suppression, and application of adequate predictive models. When HBV-HCC occurs, liver function and HCC characteristics guide the physician among treatment strategies but always considering the viral etiology in the treatment choice. MDPI 2022-05-07 /pmc/articles/PMC9146458/ /pubmed/35632728 http://dx.doi.org/10.3390/v14050986 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rizzo, Giacomo Emanuele Maria Cabibbo, Giuseppe Craxì, Antonio Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title_full | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title_fullStr | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title_full_unstemmed | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title_short | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
title_sort | hepatitis b virus-associated hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146458/ https://www.ncbi.nlm.nih.gov/pubmed/35632728 http://dx.doi.org/10.3390/v14050986 |
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