An Update on Clostridioides difficile Binary Toxin

Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsib...

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Autores principales: Martínez-Meléndez, Adrián, Cruz-López, Flora, Morfin-Otero, Rayo, Maldonado-Garza, Héctor J., Garza-González, Elvira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146464/
https://www.ncbi.nlm.nih.gov/pubmed/35622552
http://dx.doi.org/10.3390/toxins14050305
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author Martínez-Meléndez, Adrián
Cruz-López, Flora
Morfin-Otero, Rayo
Maldonado-Garza, Héctor J.
Garza-González, Elvira
author_facet Martínez-Meléndez, Adrián
Cruz-López, Flora
Morfin-Otero, Rayo
Maldonado-Garza, Héctor J.
Garza-González, Elvira
author_sort Martínez-Meléndez, Adrián
collection PubMed
description Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of C. difficile strains produce a binary toxin (CDT) encoded by the tcdA and tcdB genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches.
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spelling pubmed-91464642022-05-29 An Update on Clostridioides difficile Binary Toxin Martínez-Meléndez, Adrián Cruz-López, Flora Morfin-Otero, Rayo Maldonado-Garza, Héctor J. Garza-González, Elvira Toxins (Basel) Review Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of C. difficile strains produce a binary toxin (CDT) encoded by the tcdA and tcdB genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches. MDPI 2022-04-27 /pmc/articles/PMC9146464/ /pubmed/35622552 http://dx.doi.org/10.3390/toxins14050305 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martínez-Meléndez, Adrián
Cruz-López, Flora
Morfin-Otero, Rayo
Maldonado-Garza, Héctor J.
Garza-González, Elvira
An Update on Clostridioides difficile Binary Toxin
title An Update on Clostridioides difficile Binary Toxin
title_full An Update on Clostridioides difficile Binary Toxin
title_fullStr An Update on Clostridioides difficile Binary Toxin
title_full_unstemmed An Update on Clostridioides difficile Binary Toxin
title_short An Update on Clostridioides difficile Binary Toxin
title_sort update on clostridioides difficile binary toxin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146464/
https://www.ncbi.nlm.nih.gov/pubmed/35622552
http://dx.doi.org/10.3390/toxins14050305
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