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Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data
In this study, we analyzed the effectiveness of statin therapy for the primary prevention of cardiovascular disease (CVD) in low- and medium-risk patients. Using observational data, we estimated effectiveness by emulating a hypothetical randomized clinical trial comparing statin initiators with stat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146525/ https://www.ncbi.nlm.nih.gov/pubmed/35629081 http://dx.doi.org/10.3390/jpm12050658 |
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author | Chaure-Pardos, Armando Aguilar-Palacio, Isabel Rabanaque, Mª José Lallana, Mª Jesús Maldonado, Lina Castel-Feced, Sara Librero, Julián Casasnovas, José Antonio Malo, Sara |
author_facet | Chaure-Pardos, Armando Aguilar-Palacio, Isabel Rabanaque, Mª José Lallana, Mª Jesús Maldonado, Lina Castel-Feced, Sara Librero, Julián Casasnovas, José Antonio Malo, Sara |
author_sort | Chaure-Pardos, Armando |
collection | PubMed |
description | In this study, we analyzed the effectiveness of statin therapy for the primary prevention of cardiovascular disease (CVD) in low- and medium-risk patients. Using observational data, we estimated effectiveness by emulating a hypothetical randomized clinical trial comparing statin initiators with statin non-initiators. Two approaches were used to adjust for potential confounding factors: matching and inverse probability weighting in marginal structural models. The estimates of effectiveness were obtained by intention-to-treat and per-protocol analysis. The intention-to-treat analysis revealed an absolute risk reduction of 7.2 (95% confidence interval (CI95%), −6.6–21.0) events per 1000 subjects treated for 5 years in the matched design, and 2.2 (CI95%, −3.9–8.2) in the marginal structural model. The per-protocol analysis revealed an absolute risk reduction of 16.7 (CI95%, −3.0–36) events per 1000 subjects treated for 5 years in the matched design and 5.8 (CI95%, 0.3–11.4) in the marginal structural model. The indication for statin treatment for primary prevention in individuals with low and medium cardiovascular risk appears to be inefficient, but improves with better adherence and in subjectvs with higher risk. |
format | Online Article Text |
id | pubmed-9146525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91465252022-05-29 Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data Chaure-Pardos, Armando Aguilar-Palacio, Isabel Rabanaque, Mª José Lallana, Mª Jesús Maldonado, Lina Castel-Feced, Sara Librero, Julián Casasnovas, José Antonio Malo, Sara J Pers Med Article In this study, we analyzed the effectiveness of statin therapy for the primary prevention of cardiovascular disease (CVD) in low- and medium-risk patients. Using observational data, we estimated effectiveness by emulating a hypothetical randomized clinical trial comparing statin initiators with statin non-initiators. Two approaches were used to adjust for potential confounding factors: matching and inverse probability weighting in marginal structural models. The estimates of effectiveness were obtained by intention-to-treat and per-protocol analysis. The intention-to-treat analysis revealed an absolute risk reduction of 7.2 (95% confidence interval (CI95%), −6.6–21.0) events per 1000 subjects treated for 5 years in the matched design, and 2.2 (CI95%, −3.9–8.2) in the marginal structural model. The per-protocol analysis revealed an absolute risk reduction of 16.7 (CI95%, −3.0–36) events per 1000 subjects treated for 5 years in the matched design and 5.8 (CI95%, 0.3–11.4) in the marginal structural model. The indication for statin treatment for primary prevention in individuals with low and medium cardiovascular risk appears to be inefficient, but improves with better adherence and in subjectvs with higher risk. MDPI 2022-04-20 /pmc/articles/PMC9146525/ /pubmed/35629081 http://dx.doi.org/10.3390/jpm12050658 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chaure-Pardos, Armando Aguilar-Palacio, Isabel Rabanaque, Mª José Lallana, Mª Jesús Maldonado, Lina Castel-Feced, Sara Librero, Julián Casasnovas, José Antonio Malo, Sara Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title | Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title_full | Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title_fullStr | Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title_full_unstemmed | Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title_short | Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data |
title_sort | effectiveness of statins for primary prevention of cardiovascular disease in low- and medium-risk males: a causal inference approach with observational data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146525/ https://www.ncbi.nlm.nih.gov/pubmed/35629081 http://dx.doi.org/10.3390/jpm12050658 |
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