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The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and dur...

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Detalles Bibliográficos
Autores principales: Licordari, Roberto, Sticchi, Alessandro, Mancuso, Filippo, Caracciolo, Alessandro, Muscoli, Saverio, Iacovelli, Fortunato, Ruggiero, Rossella, Scoccia, Alessandra, Cammalleri, Valeria, Pavani, Marco, Loffi, Marco, Scordino, Domenico, Ferro, Jayme, Rognoni, Andrea, Buono, Andrea, Nava, Stefano, Albani, Stefano, Colaiori, Iginio, Zilio, Filippo, Borghesi, Marco, Regazzoni, Valentina, Benenati, Stefano, Pescetelli, Fabio, De Marzo, Vincenzo, Mannarini, Antonia, Spione, Francesco, Baldassarre, Doronzo, De Benedictis, Michele, Bonmassari, Roberto, Danzi, Gian Battista, Galli, Mario, Ielasi, Alfonso, Musumeci, Giuseppe, Tomai, Fabrizio, Pasceri, Vincenzo, Porto, Italo, Patti, Giuseppe, Campo, Gianluca, Colombo, Antonio, Micari, Antonio, Giannini, Francesco, Costa, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146584/
https://www.ncbi.nlm.nih.gov/pubmed/35629052
http://dx.doi.org/10.3390/jcm11102926
Descripción
Sumario:Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.