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The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic
Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and dur...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146584/ https://www.ncbi.nlm.nih.gov/pubmed/35629052 http://dx.doi.org/10.3390/jcm11102926 |
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| author | Licordari, Roberto Sticchi, Alessandro Mancuso, Filippo Caracciolo, Alessandro Muscoli, Saverio Iacovelli, Fortunato Ruggiero, Rossella Scoccia, Alessandra Cammalleri, Valeria Pavani, Marco Loffi, Marco Scordino, Domenico Ferro, Jayme Rognoni, Andrea Buono, Andrea Nava, Stefano Albani, Stefano Colaiori, Iginio Zilio, Filippo Borghesi, Marco Regazzoni, Valentina Benenati, Stefano Pescetelli, Fabio De Marzo, Vincenzo Mannarini, Antonia Spione, Francesco Baldassarre, Doronzo De Benedictis, Michele Bonmassari, Roberto Danzi, Gian Battista Galli, Mario Ielasi, Alfonso Musumeci, Giuseppe Tomai, Fabrizio Pasceri, Vincenzo Porto, Italo Patti, Giuseppe Campo, Gianluca Colombo, Antonio Micari, Antonio Giannini, Francesco Costa, Francesco |
| author_facet | Licordari, Roberto Sticchi, Alessandro Mancuso, Filippo Caracciolo, Alessandro Muscoli, Saverio Iacovelli, Fortunato Ruggiero, Rossella Scoccia, Alessandra Cammalleri, Valeria Pavani, Marco Loffi, Marco Scordino, Domenico Ferro, Jayme Rognoni, Andrea Buono, Andrea Nava, Stefano Albani, Stefano Colaiori, Iginio Zilio, Filippo Borghesi, Marco Regazzoni, Valentina Benenati, Stefano Pescetelli, Fabio De Marzo, Vincenzo Mannarini, Antonia Spione, Francesco Baldassarre, Doronzo De Benedictis, Michele Bonmassari, Roberto Danzi, Gian Battista Galli, Mario Ielasi, Alfonso Musumeci, Giuseppe Tomai, Fabrizio Pasceri, Vincenzo Porto, Italo Patti, Giuseppe Campo, Gianluca Colombo, Antonio Micari, Antonio Giannini, Francesco Costa, Francesco |
| author_sort | Licordari, Roberto |
| collection | PubMed |
| description | Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients. |
| format | Online Article Text |
| id | pubmed-9146584 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91465842022-05-29 The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic Licordari, Roberto Sticchi, Alessandro Mancuso, Filippo Caracciolo, Alessandro Muscoli, Saverio Iacovelli, Fortunato Ruggiero, Rossella Scoccia, Alessandra Cammalleri, Valeria Pavani, Marco Loffi, Marco Scordino, Domenico Ferro, Jayme Rognoni, Andrea Buono, Andrea Nava, Stefano Albani, Stefano Colaiori, Iginio Zilio, Filippo Borghesi, Marco Regazzoni, Valentina Benenati, Stefano Pescetelli, Fabio De Marzo, Vincenzo Mannarini, Antonia Spione, Francesco Baldassarre, Doronzo De Benedictis, Michele Bonmassari, Roberto Danzi, Gian Battista Galli, Mario Ielasi, Alfonso Musumeci, Giuseppe Tomai, Fabrizio Pasceri, Vincenzo Porto, Italo Patti, Giuseppe Campo, Gianluca Colombo, Antonio Micari, Antonio Giannini, Francesco Costa, Francesco J Clin Med Article Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients. MDPI 2022-05-22 /pmc/articles/PMC9146584/ /pubmed/35629052 http://dx.doi.org/10.3390/jcm11102926 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Licordari, Roberto Sticchi, Alessandro Mancuso, Filippo Caracciolo, Alessandro Muscoli, Saverio Iacovelli, Fortunato Ruggiero, Rossella Scoccia, Alessandra Cammalleri, Valeria Pavani, Marco Loffi, Marco Scordino, Domenico Ferro, Jayme Rognoni, Andrea Buono, Andrea Nava, Stefano Albani, Stefano Colaiori, Iginio Zilio, Filippo Borghesi, Marco Regazzoni, Valentina Benenati, Stefano Pescetelli, Fabio De Marzo, Vincenzo Mannarini, Antonia Spione, Francesco Baldassarre, Doronzo De Benedictis, Michele Bonmassari, Roberto Danzi, Gian Battista Galli, Mario Ielasi, Alfonso Musumeci, Giuseppe Tomai, Fabrizio Pasceri, Vincenzo Porto, Italo Patti, Giuseppe Campo, Gianluca Colombo, Antonio Micari, Antonio Giannini, Francesco Costa, Francesco The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_full | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_fullStr | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_full_unstemmed | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_short | The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic |
| title_sort | incidence and impact of in-hospital bleeding in patients with acute coronary syndrome during the covid-19 pandemic |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146584/ https://www.ncbi.nlm.nih.gov/pubmed/35629052 http://dx.doi.org/10.3390/jcm11102926 |
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