Cargando…
Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet
Obesity treatment efficiency can be increased by targeting both central and peripheral pathways. In a previous study, we identified two natural compounds (hispidulin and p-synephrine) that affect adipocyte differentiation. We tested whether obesity treatment efficiency may be improved by adding an a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146682/ https://www.ncbi.nlm.nih.gov/pubmed/35631305 http://dx.doi.org/10.3390/nu14102164 |
_version_ | 1784716622827618304 |
---|---|
author | Lee, Dahae Lee, Ji Hwan Kim, Byoung Ha Lee, Sanghyun Kim, Dong-Wook Kang, Ki Sung |
author_facet | Lee, Dahae Lee, Ji Hwan Kim, Byoung Ha Lee, Sanghyun Kim, Dong-Wook Kang, Ki Sung |
author_sort | Lee, Dahae |
collection | PubMed |
description | Obesity treatment efficiency can be increased by targeting both central and peripheral pathways. In a previous study, we identified two natural compounds (hispidulin and p-synephrine) that affect adipocyte differentiation. We tested whether obesity treatment efficiency may be improved by adding an appetite-controlling agent to the treatment in the present study. Alkaloids, such as p-octopamine, are adrenergic agonists and are thus used as dietary supplements to achieve weight loss. Here, we assessed anti-obesity effects of a mixture of p-synephrine, p-octopamine HCl, and hispidulin (SOH) on murine preadipocyte cells and on mice receiving a high-fat diet (HFD). SOH showed stronger inhibition of the formation of red-stained lipid droplets than co-treatment with hispidulin and p-synephrine. Moreover, SOH reduced the expression of adipogenic marker proteins, including CCAAT/enhancer-binding protein alpha, CCAAT/enhancer-binding protein beta, and peroxisome proliferator-activated receptor gamma. In the HFD-induced obesity model, body weight and dietary intake were lower in mice treated with SOH than in the controls. Additionally, liver weight and the levels of alanine aminotransferase and total cholesterol were lower in SOH-treated mice than in the controls. In conclusion, our results suggest that consumption of SOH may be a potential alternative strategy to counteract obesity. |
format | Online Article Text |
id | pubmed-9146682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91466822022-05-29 Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet Lee, Dahae Lee, Ji Hwan Kim, Byoung Ha Lee, Sanghyun Kim, Dong-Wook Kang, Ki Sung Nutrients Article Obesity treatment efficiency can be increased by targeting both central and peripheral pathways. In a previous study, we identified two natural compounds (hispidulin and p-synephrine) that affect adipocyte differentiation. We tested whether obesity treatment efficiency may be improved by adding an appetite-controlling agent to the treatment in the present study. Alkaloids, such as p-octopamine, are adrenergic agonists and are thus used as dietary supplements to achieve weight loss. Here, we assessed anti-obesity effects of a mixture of p-synephrine, p-octopamine HCl, and hispidulin (SOH) on murine preadipocyte cells and on mice receiving a high-fat diet (HFD). SOH showed stronger inhibition of the formation of red-stained lipid droplets than co-treatment with hispidulin and p-synephrine. Moreover, SOH reduced the expression of adipogenic marker proteins, including CCAAT/enhancer-binding protein alpha, CCAAT/enhancer-binding protein beta, and peroxisome proliferator-activated receptor gamma. In the HFD-induced obesity model, body weight and dietary intake were lower in mice treated with SOH than in the controls. Additionally, liver weight and the levels of alanine aminotransferase and total cholesterol were lower in SOH-treated mice than in the controls. In conclusion, our results suggest that consumption of SOH may be a potential alternative strategy to counteract obesity. MDPI 2022-05-23 /pmc/articles/PMC9146682/ /pubmed/35631305 http://dx.doi.org/10.3390/nu14102164 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Dahae Lee, Ji Hwan Kim, Byoung Ha Lee, Sanghyun Kim, Dong-Wook Kang, Ki Sung Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title | Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title_full | Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title_fullStr | Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title_full_unstemmed | Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title_short | Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet |
title_sort | phytochemical combination (p-synephrine, p-octopamine hydrochloride, and hispidulin) for improving obesity in obese mice induced by high-fat diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146682/ https://www.ncbi.nlm.nih.gov/pubmed/35631305 http://dx.doi.org/10.3390/nu14102164 |
work_keys_str_mv | AT leedahae phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet AT leejihwan phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet AT kimbyoungha phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet AT leesanghyun phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet AT kimdongwook phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet AT kangkisung phytochemicalcombinationpsynephrinepoctopaminehydrochlorideandhispidulinforimprovingobesityinobesemiceinducedbyhighfatdiet |