Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model

The mitochondrial permeability transition pore (mPTP) is a non-selective pore in the inner mitochondrial membrane (IMM) which causes depolarization when it opens under conditions of oxidative stress and high concentrations of Ca(2+). In this study, a stochastic computational model was developed to b...

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Detalles Bibliográficos
Autores principales: Yalamanchili, Keertana, Afzal, Nasrin, Boyman, Liron, Mannella, Carmen A., Lederer, W. Jonathan, Jafri, M. Saleet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146742/
https://www.ncbi.nlm.nih.gov/pubmed/35629820
http://dx.doi.org/10.3390/membranes12050494

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