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Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm

Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration r...

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Autores principales: Mo, Jingshan, Liu, Junqing, Huang, Shuang, Liang, Baoming, Huang, Xinshuo, Yang, Cheng, Chen, Meiwan, Liu, Jing, Zhang, Tong, Xie, Xi, Guo, Jun, Liu, Fanmao, Chen, Hui-Jiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146767/
https://www.ncbi.nlm.nih.gov/pubmed/35630185
http://dx.doi.org/10.3390/mi13050718
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author Mo, Jingshan
Liu, Junqing
Huang, Shuang
Liang, Baoming
Huang, Xinshuo
Yang, Cheng
Chen, Meiwan
Liu, Jing
Zhang, Tong
Xie, Xi
Guo, Jun
Liu, Fanmao
Chen, Hui-Jiuan
author_facet Mo, Jingshan
Liu, Junqing
Huang, Shuang
Liang, Baoming
Huang, Xinshuo
Yang, Cheng
Chen, Meiwan
Liu, Jing
Zhang, Tong
Xie, Xi
Guo, Jun
Liu, Fanmao
Chen, Hui-Jiuan
author_sort Mo, Jingshan
collection PubMed
description Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle interface. In this study, we demonstrated a methodology of determination of transdermal rate of metallic microneedle array through impedance measurements-based numerical check screening algorithm. Metallic sheet microneedle array sensors with different sizes were fabricated to evaluate different transdermal rates. In vitro sensing of hydrogen peroxide confirmed the effect of transdermal rate on the sensing outcomes. An FEM simulation model of a microneedle array revealed the monotonous relation between the transdermal state and test current. Accordingly, two methods were primely derived to calculate the transdermal rate from the test current. First, an exact logic method provided the number of unpenetrated tips per sheet, but it required more rigorous testing results. Second, a fuzzy logic method provided an approximate transdermal rate on adjacent areas, being more applicable and robust to errors. Real-time transdermal rate estimation may be essential for improving the performance of microneedle systems, and this study provides various fundaments toward that goal.
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spelling pubmed-91467672022-05-29 Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm Mo, Jingshan Liu, Junqing Huang, Shuang Liang, Baoming Huang, Xinshuo Yang, Cheng Chen, Meiwan Liu, Jing Zhang, Tong Xie, Xi Guo, Jun Liu, Fanmao Chen, Hui-Jiuan Micromachines (Basel) Article Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle interface. In this study, we demonstrated a methodology of determination of transdermal rate of metallic microneedle array through impedance measurements-based numerical check screening algorithm. Metallic sheet microneedle array sensors with different sizes were fabricated to evaluate different transdermal rates. In vitro sensing of hydrogen peroxide confirmed the effect of transdermal rate on the sensing outcomes. An FEM simulation model of a microneedle array revealed the monotonous relation between the transdermal state and test current. Accordingly, two methods were primely derived to calculate the transdermal rate from the test current. First, an exact logic method provided the number of unpenetrated tips per sheet, but it required more rigorous testing results. Second, a fuzzy logic method provided an approximate transdermal rate on adjacent areas, being more applicable and robust to errors. Real-time transdermal rate estimation may be essential for improving the performance of microneedle systems, and this study provides various fundaments toward that goal. MDPI 2022-04-30 /pmc/articles/PMC9146767/ /pubmed/35630185 http://dx.doi.org/10.3390/mi13050718 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mo, Jingshan
Liu, Junqing
Huang, Shuang
Liang, Baoming
Huang, Xinshuo
Yang, Cheng
Chen, Meiwan
Liu, Jing
Zhang, Tong
Xie, Xi
Guo, Jun
Liu, Fanmao
Chen, Hui-Jiuan
Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title_full Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title_fullStr Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title_full_unstemmed Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title_short Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm
title_sort determination of transdermal rate of metallic microneedle array through an impedance measurements-based numerical check screening algorithm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146767/
https://www.ncbi.nlm.nih.gov/pubmed/35630185
http://dx.doi.org/10.3390/mi13050718
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