Cargando…
Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19?
The COVID-19 pandemic may have had an effect on antimicrobial resistance. We compared the prevalence of ESKAPE multidrug-resistant (MDR) bacterial infections in COVID-19 affected/unaffected patients admitted to intensive care units (ICU) or infectious disease units at the “Mater Domini” University H...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146770/ https://www.ncbi.nlm.nih.gov/pubmed/35630400 http://dx.doi.org/10.3390/microorganisms10050957 |
_version_ | 1784716644562501632 |
---|---|
author | Serapide, Francesca Quirino, Angela Scaglione, Vincenzo Morrone, Helen Linda Longhini, Federico Bruni, Andrea Garofalo, Eugenio Matera, Giovanni Marascio, Nadia Scarlata, Giuseppe Guido Maria Cicino, Claudia Russo, Alessandro Trecarichi, Enrico Maria Torti, Carlo |
author_facet | Serapide, Francesca Quirino, Angela Scaglione, Vincenzo Morrone, Helen Linda Longhini, Federico Bruni, Andrea Garofalo, Eugenio Matera, Giovanni Marascio, Nadia Scarlata, Giuseppe Guido Maria Cicino, Claudia Russo, Alessandro Trecarichi, Enrico Maria Torti, Carlo |
author_sort | Serapide, Francesca |
collection | PubMed |
description | The COVID-19 pandemic may have had an effect on antimicrobial resistance. We compared the prevalence of ESKAPE multidrug-resistant (MDR) bacterial infections in COVID-19 affected/unaffected patients admitted to intensive care units (ICU) or infectious disease units at the “Mater Domini” University Hospital of Catanzaro between 1 March 2020 and 31 July 2021. Moreover, an analysis of MDR rates in ICU comparing the pre-pandemic period with the pandemic period was performed, and the possible consequence on in-hospital mortality was explored. One hundred and eighty-four ESKAPE isolates were analyzed from 362 SARS-CoV-2 positive and 199 negative patients. In total, 116 out of 171 Gram-negative isolates were classified as MDR, and a higher frequency was observed in COVID-19 compared with non-COVID-19 patients (74.2% vs. 60.3%; p = 0.052). A higher rate of MDR ESKAPE bacteria was observed in COVID-19 patients admitted to the ICU compared with COVID-19 unaffected patients admitted to the same ward in 2019 (88% vs. 80.4%; p = 0.186). Acinetobacter baumannii was the main pathogen in COVID-19 patients (58.7%), where it was the most frequent cause of bloodstream infection with the highest mortality rate (68.7%). Increase in MDR appeared to be associated with COVID-19 but only in the ICU setting. Acinetobacter baumannii was associated with the risk of death, indicating the importance of implementing infection control measures urgently. |
format | Online Article Text |
id | pubmed-9146770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91467702022-05-29 Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? Serapide, Francesca Quirino, Angela Scaglione, Vincenzo Morrone, Helen Linda Longhini, Federico Bruni, Andrea Garofalo, Eugenio Matera, Giovanni Marascio, Nadia Scarlata, Giuseppe Guido Maria Cicino, Claudia Russo, Alessandro Trecarichi, Enrico Maria Torti, Carlo Microorganisms Communication The COVID-19 pandemic may have had an effect on antimicrobial resistance. We compared the prevalence of ESKAPE multidrug-resistant (MDR) bacterial infections in COVID-19 affected/unaffected patients admitted to intensive care units (ICU) or infectious disease units at the “Mater Domini” University Hospital of Catanzaro between 1 March 2020 and 31 July 2021. Moreover, an analysis of MDR rates in ICU comparing the pre-pandemic period with the pandemic period was performed, and the possible consequence on in-hospital mortality was explored. One hundred and eighty-four ESKAPE isolates were analyzed from 362 SARS-CoV-2 positive and 199 negative patients. In total, 116 out of 171 Gram-negative isolates were classified as MDR, and a higher frequency was observed in COVID-19 compared with non-COVID-19 patients (74.2% vs. 60.3%; p = 0.052). A higher rate of MDR ESKAPE bacteria was observed in COVID-19 patients admitted to the ICU compared with COVID-19 unaffected patients admitted to the same ward in 2019 (88% vs. 80.4%; p = 0.186). Acinetobacter baumannii was the main pathogen in COVID-19 patients (58.7%), where it was the most frequent cause of bloodstream infection with the highest mortality rate (68.7%). Increase in MDR appeared to be associated with COVID-19 but only in the ICU setting. Acinetobacter baumannii was associated with the risk of death, indicating the importance of implementing infection control measures urgently. MDPI 2022-05-02 /pmc/articles/PMC9146770/ /pubmed/35630400 http://dx.doi.org/10.3390/microorganisms10050957 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Serapide, Francesca Quirino, Angela Scaglione, Vincenzo Morrone, Helen Linda Longhini, Federico Bruni, Andrea Garofalo, Eugenio Matera, Giovanni Marascio, Nadia Scarlata, Giuseppe Guido Maria Cicino, Claudia Russo, Alessandro Trecarichi, Enrico Maria Torti, Carlo Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title | Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title_full | Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title_fullStr | Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title_full_unstemmed | Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title_short | Is the Pendulum of Antimicrobial Drug Resistance Swinging Back after COVID-19? |
title_sort | is the pendulum of antimicrobial drug resistance swinging back after covid-19? |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146770/ https://www.ncbi.nlm.nih.gov/pubmed/35630400 http://dx.doi.org/10.3390/microorganisms10050957 |
work_keys_str_mv | AT serapidefrancesca isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT quirinoangela isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT scaglionevincenzo isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT morronehelenlinda isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT longhinifederico isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT bruniandrea isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT garofaloeugenio isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT materagiovanni isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT marascionadia isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT scarlatagiuseppeguidomaria isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT cicinoclaudia isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT russoalessandro isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT trecarichienricomaria isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 AT torticarlo isthependulumofantimicrobialdrugresistanceswingingbackaftercovid19 |