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Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients

Background: Gender-specific differences in the outcome of COVID-19 patients requiring intensive care treatment have been reported. However, a potential association with ICU therapy remains elusive. Methods: A total of 224 consecutive patients (63 women) treated for severe COVID-19 disease requiring...

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Autores principales: Jirak, Peter, Mirna, Moritz, Van Almsick, Vincent, Shomanova, Zornitsa, Mahringer, Magdalena, Lichtenauer, Michael, Kopp, Kristen, Topf, Albert, Sieg, Franz, Kraus, Johannes, Gharibeh, Sarah X., Hoppe, Uta C., Fiedler, Lukas, Larbig, Robert, Pistulli, Rudin, Motloch, Lukas J., Dieplinger, Anna-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146781/
https://www.ncbi.nlm.nih.gov/pubmed/35629271
http://dx.doi.org/10.3390/jpm12050849
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author Jirak, Peter
Mirna, Moritz
Van Almsick, Vincent
Shomanova, Zornitsa
Mahringer, Magdalena
Lichtenauer, Michael
Kopp, Kristen
Topf, Albert
Sieg, Franz
Kraus, Johannes
Gharibeh, Sarah X.
Hoppe, Uta C.
Fiedler, Lukas
Larbig, Robert
Pistulli, Rudin
Motloch, Lukas J.
Dieplinger, Anna-Maria
author_facet Jirak, Peter
Mirna, Moritz
Van Almsick, Vincent
Shomanova, Zornitsa
Mahringer, Magdalena
Lichtenauer, Michael
Kopp, Kristen
Topf, Albert
Sieg, Franz
Kraus, Johannes
Gharibeh, Sarah X.
Hoppe, Uta C.
Fiedler, Lukas
Larbig, Robert
Pistulli, Rudin
Motloch, Lukas J.
Dieplinger, Anna-Maria
author_sort Jirak, Peter
collection PubMed
description Background: Gender-specific differences in the outcome of COVID-19 patients requiring intensive care treatment have been reported. However, a potential association with ICU therapy remains elusive. Methods: A total of 224 consecutive patients (63 women) treated for severe COVID-19 disease requiring mechanical ventilation were screened for the study. After propensity score matching for gender, 40 men and 40 women were included in the study. Comparative analysis was conducted for laboratory parameters, ICU therapy and complications (pulmonary embolism, thrombosis, stroke, and ventricular arrhythmias), and outcome (mortality). Results: Male patients had significantly higher levels of CRP (p = 0.012), interleukin-6 (p = 0.020) and creatinine (p = 0.027), while pH levels (p = 0.014) were significantly lower compared to females. Male patients had longer intubation times (p = 0.017), longer ICU stays (p = 0.022) and higher rates of catecholamine dependence (p = 0.037). Outcome, complications and ICU therapy did not differ significantly between both groups. Conclusion: The present study represents the first matched comparison of male and female COVID-19 patients requiring intensive care treatment. After propensity matching, male patients still displayed a higher disease severity. This was reflected in higher rates of vasopressors, duration of ICU stay and duration of intubation. In contrast, no significant differences were observed in mortality rates, organ replacement therapy and complications during ICU stay.
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spelling pubmed-91467812022-05-29 Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients Jirak, Peter Mirna, Moritz Van Almsick, Vincent Shomanova, Zornitsa Mahringer, Magdalena Lichtenauer, Michael Kopp, Kristen Topf, Albert Sieg, Franz Kraus, Johannes Gharibeh, Sarah X. Hoppe, Uta C. Fiedler, Lukas Larbig, Robert Pistulli, Rudin Motloch, Lukas J. Dieplinger, Anna-Maria J Pers Med Article Background: Gender-specific differences in the outcome of COVID-19 patients requiring intensive care treatment have been reported. However, a potential association with ICU therapy remains elusive. Methods: A total of 224 consecutive patients (63 women) treated for severe COVID-19 disease requiring mechanical ventilation were screened for the study. After propensity score matching for gender, 40 men and 40 women were included in the study. Comparative analysis was conducted for laboratory parameters, ICU therapy and complications (pulmonary embolism, thrombosis, stroke, and ventricular arrhythmias), and outcome (mortality). Results: Male patients had significantly higher levels of CRP (p = 0.012), interleukin-6 (p = 0.020) and creatinine (p = 0.027), while pH levels (p = 0.014) were significantly lower compared to females. Male patients had longer intubation times (p = 0.017), longer ICU stays (p = 0.022) and higher rates of catecholamine dependence (p = 0.037). Outcome, complications and ICU therapy did not differ significantly between both groups. Conclusion: The present study represents the first matched comparison of male and female COVID-19 patients requiring intensive care treatment. After propensity matching, male patients still displayed a higher disease severity. This was reflected in higher rates of vasopressors, duration of ICU stay and duration of intubation. In contrast, no significant differences were observed in mortality rates, organ replacement therapy and complications during ICU stay. MDPI 2022-05-23 /pmc/articles/PMC9146781/ /pubmed/35629271 http://dx.doi.org/10.3390/jpm12050849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jirak, Peter
Mirna, Moritz
Van Almsick, Vincent
Shomanova, Zornitsa
Mahringer, Magdalena
Lichtenauer, Michael
Kopp, Kristen
Topf, Albert
Sieg, Franz
Kraus, Johannes
Gharibeh, Sarah X.
Hoppe, Uta C.
Fiedler, Lukas
Larbig, Robert
Pistulli, Rudin
Motloch, Lukas J.
Dieplinger, Anna-Maria
Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title_full Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title_fullStr Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title_full_unstemmed Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title_short Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients
title_sort gender-specific differences in the intensive care treatment of covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146781/
https://www.ncbi.nlm.nih.gov/pubmed/35629271
http://dx.doi.org/10.3390/jpm12050849
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