A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules...

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Detalles Bibliográficos
Autores principales: Chowdhary, Shefali, Shalini, Arora, Amandeep, Kumar, Vipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146800/
https://www.ncbi.nlm.nih.gov/pubmed/35631362
http://dx.doi.org/10.3390/ph15050536
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author Chowdhary, Shefali
Shalini,
Arora, Amandeep
Kumar, Vipan
author_facet Chowdhary, Shefali
Shalini,
Arora, Amandeep
Kumar, Vipan
author_sort Chowdhary, Shefali
collection PubMed
description Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in trials. Apart from its promising antiproliferative properties, isatin has shown potential in treating Neglected Tropical Diseases (NTDs) not only as a parent core, but also by attenuating the activities of various pharmacophores. The objective of this mini-review is to keep readers up to date on the latest developments in the biological potential of isatin-based scaffolds, targeting cancer and NTDs such as tuberculosis, malaria, and microbial infections.
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spelling pubmed-91468002022-05-29 A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs) Chowdhary, Shefali Shalini, Arora, Amandeep Kumar, Vipan Pharmaceuticals (Basel) Review Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in trials. Apart from its promising antiproliferative properties, isatin has shown potential in treating Neglected Tropical Diseases (NTDs) not only as a parent core, but also by attenuating the activities of various pharmacophores. The objective of this mini-review is to keep readers up to date on the latest developments in the biological potential of isatin-based scaffolds, targeting cancer and NTDs such as tuberculosis, malaria, and microbial infections. MDPI 2022-04-27 /pmc/articles/PMC9146800/ /pubmed/35631362 http://dx.doi.org/10.3390/ph15050536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chowdhary, Shefali
Shalini,
Arora, Amandeep
Kumar, Vipan
A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title_full A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title_fullStr A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title_full_unstemmed A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title_short A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)
title_sort mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (ntds)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146800/
https://www.ncbi.nlm.nih.gov/pubmed/35631362
http://dx.doi.org/10.3390/ph15050536
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