Cargando…
Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study
Background: Non-T2 asthma and hypothyroidism share several inflammatory mechanisms in common. However, large-scale, real-world studies evaluating the association between asthma and hypothyroidism are lacking. The objective of this study was to evaluate the risk for asthma patients of developing hypo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146804/ https://www.ncbi.nlm.nih.gov/pubmed/35628903 http://dx.doi.org/10.3390/jcm11102776 |
_version_ | 1784716652810600448 |
---|---|
author | Huang, Shih-Cheng Gau, Shuo-Yan Huang, Jing-Yang Wu, Wen-Jun Wei, James Cheng-Chung |
author_facet | Huang, Shih-Cheng Gau, Shuo-Yan Huang, Jing-Yang Wu, Wen-Jun Wei, James Cheng-Chung |
author_sort | Huang, Shih-Cheng |
collection | PubMed |
description | Background: Non-T2 asthma and hypothyroidism share several inflammatory mechanisms in common. However, large-scale, real-world studies evaluating the association between asthma and hypothyroidism are lacking. The objective of this study was to evaluate the risk for asthma patients of developing hypothyroidism. Methods: In the retrospective cohort study, people with asthma were recruited from the Longitudinal Health Insurance Database in Taiwan. After excluding ineligible patients with a previous history of hypothyroidism, 1:1 propensity matching was conducted to select a non-asthma control group. Based on the multivariate Cox regression model, the adjusted hazard ratio of asthma patients developing hypothyroidism was calculated. Results: In total, 95,321 asthma patients were selected as the asthma group and the same amount of people without asthma were selected as the control group. The incidence levels of new-onset hypothyroidism in asthma and non-asthma groups were 8.13 and 6.83 per 100,000 people per year, respectively. Compared with the non-asthma group, the adjusted hazard ratio of the asthma group developing hypothyroidism was 1.217 (95% confidence interval, 1.091–1.357). Conclusions: We found having asthma to be associated with an increased risk of hypothyroidism. Clinicians should be concerned regarding the endocrinological and inflammatory interaction between the two diseases while caring for people with asthma. |
format | Online Article Text |
id | pubmed-9146804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91468042022-05-29 Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study Huang, Shih-Cheng Gau, Shuo-Yan Huang, Jing-Yang Wu, Wen-Jun Wei, James Cheng-Chung J Clin Med Article Background: Non-T2 asthma and hypothyroidism share several inflammatory mechanisms in common. However, large-scale, real-world studies evaluating the association between asthma and hypothyroidism are lacking. The objective of this study was to evaluate the risk for asthma patients of developing hypothyroidism. Methods: In the retrospective cohort study, people with asthma were recruited from the Longitudinal Health Insurance Database in Taiwan. After excluding ineligible patients with a previous history of hypothyroidism, 1:1 propensity matching was conducted to select a non-asthma control group. Based on the multivariate Cox regression model, the adjusted hazard ratio of asthma patients developing hypothyroidism was calculated. Results: In total, 95,321 asthma patients were selected as the asthma group and the same amount of people without asthma were selected as the control group. The incidence levels of new-onset hypothyroidism in asthma and non-asthma groups were 8.13 and 6.83 per 100,000 people per year, respectively. Compared with the non-asthma group, the adjusted hazard ratio of the asthma group developing hypothyroidism was 1.217 (95% confidence interval, 1.091–1.357). Conclusions: We found having asthma to be associated with an increased risk of hypothyroidism. Clinicians should be concerned regarding the endocrinological and inflammatory interaction between the two diseases while caring for people with asthma. MDPI 2022-05-14 /pmc/articles/PMC9146804/ /pubmed/35628903 http://dx.doi.org/10.3390/jcm11102776 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Shih-Cheng Gau, Shuo-Yan Huang, Jing-Yang Wu, Wen-Jun Wei, James Cheng-Chung Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title | Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title_full | Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title_fullStr | Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title_full_unstemmed | Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title_short | Increased Risk of Hypothyroidism in People with Asthma: Evidence from a Real-World Population-Based Study |
title_sort | increased risk of hypothyroidism in people with asthma: evidence from a real-world population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146804/ https://www.ncbi.nlm.nih.gov/pubmed/35628903 http://dx.doi.org/10.3390/jcm11102776 |
work_keys_str_mv | AT huangshihcheng increasedriskofhypothyroidisminpeoplewithasthmaevidencefromarealworldpopulationbasedstudy AT gaushuoyan increasedriskofhypothyroidisminpeoplewithasthmaevidencefromarealworldpopulationbasedstudy AT huangjingyang increasedriskofhypothyroidisminpeoplewithasthmaevidencefromarealworldpopulationbasedstudy AT wuwenjun increasedriskofhypothyroidisminpeoplewithasthmaevidencefromarealworldpopulationbasedstudy AT weijameschengchung increasedriskofhypothyroidisminpeoplewithasthmaevidencefromarealworldpopulationbasedstudy |