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Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles
A diverse series of imine linked 1,2,3-triazole hybrids has been synthesized via Cu(I)-promoted click reaction, with an aim to develop some new antimicrobial molecules. The structural characterization of the synthesized triazole hybrids was accomplished using various spectral techniques like (1)H NM...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146814/ http://dx.doi.org/10.1007/s11164-022-04737-2 |
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author | Kumar, Aman Lal, Kashmiri Poonia, Nisha Kumar, Ashwani Kumar, Anil |
author_facet | Kumar, Aman Lal, Kashmiri Poonia, Nisha Kumar, Ashwani Kumar, Anil |
author_sort | Kumar, Aman |
collection | PubMed |
description | A diverse series of imine linked 1,2,3-triazole hybrids has been synthesized via Cu(I)-promoted click reaction, with an aim to develop some new antimicrobial molecules. The structural characterization of the synthesized triazole hybrids was accomplished using various spectral techniques like (1)H NMR, (13)C NMR, FTIR and HRMS. Among the synthesized hybrids, 7d exhibited highest antimicrobial efficacy against R. oryzae and S. aureus with MIC of 0.0123 µmol/mL and 0.0061 µmol/mL, respectively. Docking studies of the terminal alkynes (4a, 4b) and triazole hybrids (6a, 6d, 7c, 7g) showing high potency towards E. coli DNA gyrase and C. albicans sterol 14-α demethylase were also undertaken to understand the binding behaviour. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11164-022-04737-2. |
format | Online Article Text |
id | pubmed-9146814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-91468142022-06-02 Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles Kumar, Aman Lal, Kashmiri Poonia, Nisha Kumar, Ashwani Kumar, Anil Res Chem Intermed Article A diverse series of imine linked 1,2,3-triazole hybrids has been synthesized via Cu(I)-promoted click reaction, with an aim to develop some new antimicrobial molecules. The structural characterization of the synthesized triazole hybrids was accomplished using various spectral techniques like (1)H NMR, (13)C NMR, FTIR and HRMS. Among the synthesized hybrids, 7d exhibited highest antimicrobial efficacy against R. oryzae and S. aureus with MIC of 0.0123 µmol/mL and 0.0061 µmol/mL, respectively. Docking studies of the terminal alkynes (4a, 4b) and triazole hybrids (6a, 6d, 7c, 7g) showing high potency towards E. coli DNA gyrase and C. albicans sterol 14-α demethylase were also undertaken to understand the binding behaviour. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11164-022-04737-2. Springer Netherlands 2022-05-28 2022 /pmc/articles/PMC9146814/ http://dx.doi.org/10.1007/s11164-022-04737-2 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Kumar, Aman Lal, Kashmiri Poonia, Nisha Kumar, Ashwani Kumar, Anil Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title | Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title_full | Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title_fullStr | Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title_full_unstemmed | Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title_short | Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
title_sort | synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146814/ http://dx.doi.org/10.1007/s11164-022-04737-2 |
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