Cargando…

Neuroprotective Effect of Dioscin against Parkinson’s Disease via Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative Stress

Exploration of lead compounds against Parkinson’s disease (PD), a neurodegenerative disease, is of great important. Dioscin, a bioactive natural product, shows various pharmacological effects. However, the activities and mechanisms of dioscin against PD have not been well investigated. In this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mao, Zhang, Gao, Meng, Zhao, Xuerong, Li, Lili, Peng, Jinyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146847/ https://www.ncbi.nlm.nih.gov/pubmed/35630630 http://dx.doi.org/10.3390/molecules27103151

Ejemplares similares

Neuroprotective Effect of Dioscin on the Aging Brain
por: Qi, Yan, et al.
Publicado: (2019)

Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
por: Mao, Zhang, et al.
Publicado: (2023)

Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer
por: Ahmad, Muhammad Khairi, et al.
Publicado: (2018)

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement
por: Zuchegna, Candida, et al.
Publicado: (2020)

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells
por: Benito-León, María, et al.
Publicado: (2022)

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress
por: Zhao, Lisha, et al.
Publicado: (2018)

Potent effects of dioscin against liver fibrosis
por: Zhang, Xiaoling, et al.
Publicado: (2015)

Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics
por: Yin, Lianhong, et al.
Publicado: (2017)

Potent effects of dioscin against obesity in mice
por: Liu, Min, et al.
Publicado: (2015)

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability
por: Chen, Hsueh-Fen, et al.
Publicado: (2019)

Corrigendum: Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights From iTRAQ-Based Quantitative Proteomics
por: Yin, Lianhong, et al.
Publicado: (2019)

Corrigendum: Potent effects of dioscin against obesity in mice
por: Liu, Min, et al.
Publicado: (2015)

Dual Specificity Phosphatase 6 (DUSP6) regulates CD4+ T cell functions and restrains the spontaneous colitis in IL-10 deficient mice
por: Bertin, Samuel, et al.
Publicado: (2014)

Author Correction: Potent effects of dioscin against obesity in mice
por: Liu, Min, et al.
Publicado: (2020)

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
por: Amand, Mathieu, et al.
Publicado: (2014)

Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance
por: Singh, Mithalesh K., et al.
Publicado: (2022)

Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease
por: Wang, Erming, et al.
Publicado: (2023)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer
por: Moncho-Amor, Verónica, et al.
Publicado: (2019)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity
por: Jiménez-Martínez, Marta, et al.
Publicado: (2019)

Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway
por: Ha, Jain, et al.
Publicado: (2019)

Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation
por: Yao, Hong, et al.
Publicado: (2017)

DUSP4 phosphatase puts the brakes on DLBCL
por: Rickert, Robert
Publicado: (2015)

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids
por: Shipp, Lauren E., et al.
Publicado: (2010)

Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia
por: Chen, Lauren L, et al.
Publicado: (2019)

Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese
por: Wang, Tian-Lu, et al.
Publicado: (2017)

Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress
por: Yao, Hong, et al.
Publicado: (2017)

Expression of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) in Tumor Cells
por: Staege, Martin S., et al.
Publicado: (2014)

DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases
por: Khoubai, Fatma Zohra, et al.
Publicado: (2021)

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
por: Ge, Chenxu, et al.
Publicado: (2022)

Involvement of the Cellular Phosphatase DUSP1 in Vaccinia Virus Infection
por: Cáceres, Ana, et al.
Publicado: (2013)

Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
por: Russo, Lilian Cristina, et al.
Publicado: (2018)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

Dioscin Inhibits Virulence Factors of Candida albicans
por: Yang, Longfei, et al.
Publicado: (2018)

The Dual-Specificity Phosphatase 2 (DUSP2) Does Not Regulate Obesity-Associated Inflammation or Insulin Resistance in Mice
por: Lancaster, Graeme I., et al.
Publicado: (2014)

Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma
por: Gupta, Avinash, et al.
Publicado: (2019)

A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding
por: Shillingford, Shanelle, et al.
Publicado: (2022)

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea
por: Bermúdez-Muñoz, Jose M., et al.
Publicado: (2021)

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
por: Arora, Deepika, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7pg04qn8o7d6dvs22crg4ittd1