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Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals
Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomita...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146859/ https://www.ncbi.nlm.nih.gov/pubmed/35628408 http://dx.doi.org/10.3390/ijms23105592 |
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author | Jiménez-Osorio, Angélica Saraí Jaen-Vega, Sinaí Fernández-Martínez, Eduardo Ortíz-Rodríguez, María Araceli Martínez-Salazar, María Fernanda Jiménez-Sánchez, Reyna Cristina Flores-Chávez, Olga Rocío Ramírez-Moreno, Esther Arias-Rico, José Arteaga-García, Felipe Estrada-Luna, Diego |
author_facet | Jiménez-Osorio, Angélica Saraí Jaen-Vega, Sinaí Fernández-Martínez, Eduardo Ortíz-Rodríguez, María Araceli Martínez-Salazar, María Fernanda Jiménez-Sánchez, Reyna Cristina Flores-Chávez, Olga Rocío Ramírez-Moreno, Esther Arias-Rico, José Arteaga-García, Felipe Estrada-Luna, Diego |
author_sort | Jiménez-Osorio, Angélica Saraí |
collection | PubMed |
description | Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects. |
format | Online Article Text |
id | pubmed-9146859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91468592022-05-29 Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals Jiménez-Osorio, Angélica Saraí Jaen-Vega, Sinaí Fernández-Martínez, Eduardo Ortíz-Rodríguez, María Araceli Martínez-Salazar, María Fernanda Jiménez-Sánchez, Reyna Cristina Flores-Chávez, Olga Rocío Ramírez-Moreno, Esther Arias-Rico, José Arteaga-García, Felipe Estrada-Luna, Diego Int J Mol Sci Review Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects. MDPI 2022-05-17 /pmc/articles/PMC9146859/ /pubmed/35628408 http://dx.doi.org/10.3390/ijms23105592 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jiménez-Osorio, Angélica Saraí Jaen-Vega, Sinaí Fernández-Martínez, Eduardo Ortíz-Rodríguez, María Araceli Martínez-Salazar, María Fernanda Jiménez-Sánchez, Reyna Cristina Flores-Chávez, Olga Rocío Ramírez-Moreno, Esther Arias-Rico, José Arteaga-García, Felipe Estrada-Luna, Diego Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_full | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_fullStr | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_full_unstemmed | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_short | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_sort | antiretroviral therapy-induced dysregulation of gene expression and lipid metabolism in hiv+ patients: beneficial role of antioxidant phytochemicals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146859/ https://www.ncbi.nlm.nih.gov/pubmed/35628408 http://dx.doi.org/10.3390/ijms23105592 |
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