Cargando…

Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania

SARS-CoV-2 infection produces alterations in blood clotting, especially in severe cases of COVID-19. Abnormal coagulation parameters in patients with COVID-19 are important prognostic factors of disease severity. The objective of this study was to evaluate the predictive value of aPTT, D-dimer, INR...

Descripción completa

Detalles Bibliográficos
Autores principales: Citu, Cosmin, Burlea, Bogdan, Gorun, Florin, Motoc, Andrei, Gorun, Oana Maria, Malita, Daniel, Ratiu, Adrian, Margan, Roxana, Grigoras, Mirela Loredana, Bratosin, Felix, Citu, Ioana Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146890/
https://www.ncbi.nlm.nih.gov/pubmed/35628956
http://dx.doi.org/10.3390/jcm11102831
_version_ 1784716673682505728
author Citu, Cosmin
Burlea, Bogdan
Gorun, Florin
Motoc, Andrei
Gorun, Oana Maria
Malita, Daniel
Ratiu, Adrian
Margan, Roxana
Grigoras, Mirela Loredana
Bratosin, Felix
Citu, Ioana Mihaela
author_facet Citu, Cosmin
Burlea, Bogdan
Gorun, Florin
Motoc, Andrei
Gorun, Oana Maria
Malita, Daniel
Ratiu, Adrian
Margan, Roxana
Grigoras, Mirela Loredana
Bratosin, Felix
Citu, Ioana Mihaela
author_sort Citu, Cosmin
collection PubMed
description SARS-CoV-2 infection produces alterations in blood clotting, especially in severe cases of COVID-19. Abnormal coagulation parameters in patients with COVID-19 are important prognostic factors of disease severity. The objective of this study was to evaluate the predictive value of aPTT, D-dimer, INR and PT in the mortality of patients with COVID-19. A retrospective, single-center, observational study was conducted on COVID-19 patients admitted to the Municipal Emergency Clinical Hospital in Timisoara, Romania, between August and October 2021. Patients were confirmed as COVID-19 positive by reverse transcription-polymerase chain reaction (RT-PCR) assay. After applying the inclusion/exclusion criteria, a total of 82 patients were included in the analysis. Receiver operating characteristic (ROC) curves of D-Dimer, INR, PT and aPTT were generated to assess whether the baseline of each of these biomarkers was accurately predictive for mortality in patients with COVID-19. Mortality among patients enrolled in this study was 20.7%, associated with older age and presence of heart disease. The areas under the ROC curve (AUC-ROC) of D-Dimer, INR, PT, and aPTT were 0.751, 0.724, 0.706 and 0.753. Differences in survival for patients with coagulation biomarker levels above cut-off values compared to patients below these values were statistically significant. All evaluated parameters had significant differences and good performance in predicting mortality of COVID-19 patients, except fibrinogen, which had no significant difference. Moreover, aPTT and D-dimer were the best performing parameters in predicting mortality in patients with SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-9146890
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91468902022-05-29 Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania Citu, Cosmin Burlea, Bogdan Gorun, Florin Motoc, Andrei Gorun, Oana Maria Malita, Daniel Ratiu, Adrian Margan, Roxana Grigoras, Mirela Loredana Bratosin, Felix Citu, Ioana Mihaela J Clin Med Article SARS-CoV-2 infection produces alterations in blood clotting, especially in severe cases of COVID-19. Abnormal coagulation parameters in patients with COVID-19 are important prognostic factors of disease severity. The objective of this study was to evaluate the predictive value of aPTT, D-dimer, INR and PT in the mortality of patients with COVID-19. A retrospective, single-center, observational study was conducted on COVID-19 patients admitted to the Municipal Emergency Clinical Hospital in Timisoara, Romania, between August and October 2021. Patients were confirmed as COVID-19 positive by reverse transcription-polymerase chain reaction (RT-PCR) assay. After applying the inclusion/exclusion criteria, a total of 82 patients were included in the analysis. Receiver operating characteristic (ROC) curves of D-Dimer, INR, PT and aPTT were generated to assess whether the baseline of each of these biomarkers was accurately predictive for mortality in patients with COVID-19. Mortality among patients enrolled in this study was 20.7%, associated with older age and presence of heart disease. The areas under the ROC curve (AUC-ROC) of D-Dimer, INR, PT, and aPTT were 0.751, 0.724, 0.706 and 0.753. Differences in survival for patients with coagulation biomarker levels above cut-off values compared to patients below these values were statistically significant. All evaluated parameters had significant differences and good performance in predicting mortality of COVID-19 patients, except fibrinogen, which had no significant difference. Moreover, aPTT and D-dimer were the best performing parameters in predicting mortality in patients with SARS-CoV-2 infection. MDPI 2022-05-17 /pmc/articles/PMC9146890/ /pubmed/35628956 http://dx.doi.org/10.3390/jcm11102831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Citu, Cosmin
Burlea, Bogdan
Gorun, Florin
Motoc, Andrei
Gorun, Oana Maria
Malita, Daniel
Ratiu, Adrian
Margan, Roxana
Grigoras, Mirela Loredana
Bratosin, Felix
Citu, Ioana Mihaela
Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title_full Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title_fullStr Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title_full_unstemmed Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title_short Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania
title_sort predictive value of blood coagulation parameters in poor outcomes in covid-19 patients: a retrospective observational study in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146890/
https://www.ncbi.nlm.nih.gov/pubmed/35628956
http://dx.doi.org/10.3390/jcm11102831
work_keys_str_mv AT citucosmin predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT burleabogdan predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT gorunflorin predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT motocandrei predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT gorunoanamaria predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT malitadaniel predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT ratiuadrian predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT marganroxana predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT grigorasmirelaloredana predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT bratosinfelix predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania
AT cituioanamihaela predictivevalueofbloodcoagulationparametersinpooroutcomesincovid19patientsaretrospectiveobservationalstudyinromania