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A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146940/ https://www.ncbi.nlm.nih.gov/pubmed/35630190 http://dx.doi.org/10.3390/mi13050723 |
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author | Hassan, Rubayet Cesmeci, Sevki Baniasadi, Mahmoud Palacio, Anthony Robbins, Austin |
author_facet | Hassan, Rubayet Cesmeci, Sevki Baniasadi, Mahmoud Palacio, Anthony Robbins, Austin |
author_sort | Hassan, Rubayet |
collection | PubMed |
description | In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed with the previously published data in the literature to ensure the accuracy of the simulations. The proposed optimum duckbill valve micropump can pump 2.45 µL of fluid during the first 1 s, including both contraction and expansion phases, almost 16.67% more than the basic model. In addition, the model can pump a maximum volume of 0.26 µL of fluid at the end of the contraction phase (at 0.5 s) when the magnetic flux density is at maximum (0.027 T). The use of a duckbill valve in the model also reduces the backflow by almost 7.5 times more than the model without any valve. The proposed device could potentially be used in a broad range of applications, such as an insulin dosing system for Type 1 diabetic patients, artificial organs to transport blood, organ-on-chip applications, and so on. |
format | Online Article Text |
id | pubmed-9146940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91469402022-05-29 A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications Hassan, Rubayet Cesmeci, Sevki Baniasadi, Mahmoud Palacio, Anthony Robbins, Austin Micromachines (Basel) Article In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed with the previously published data in the literature to ensure the accuracy of the simulations. The proposed optimum duckbill valve micropump can pump 2.45 µL of fluid during the first 1 s, including both contraction and expansion phases, almost 16.67% more than the basic model. In addition, the model can pump a maximum volume of 0.26 µL of fluid at the end of the contraction phase (at 0.5 s) when the magnetic flux density is at maximum (0.027 T). The use of a duckbill valve in the model also reduces the backflow by almost 7.5 times more than the model without any valve. The proposed device could potentially be used in a broad range of applications, such as an insulin dosing system for Type 1 diabetic patients, artificial organs to transport blood, organ-on-chip applications, and so on. MDPI 2022-04-30 /pmc/articles/PMC9146940/ /pubmed/35630190 http://dx.doi.org/10.3390/mi13050723 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hassan, Rubayet Cesmeci, Sevki Baniasadi, Mahmoud Palacio, Anthony Robbins, Austin A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title | A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title_full | A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title_fullStr | A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title_full_unstemmed | A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title_short | A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications |
title_sort | magnetorheological duckbill valve micropump for drug delivery applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146940/ https://www.ncbi.nlm.nih.gov/pubmed/35630190 http://dx.doi.org/10.3390/mi13050723 |
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