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A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications

In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed w...

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Autores principales: Hassan, Rubayet, Cesmeci, Sevki, Baniasadi, Mahmoud, Palacio, Anthony, Robbins, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146940/
https://www.ncbi.nlm.nih.gov/pubmed/35630190
http://dx.doi.org/10.3390/mi13050723
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author Hassan, Rubayet
Cesmeci, Sevki
Baniasadi, Mahmoud
Palacio, Anthony
Robbins, Austin
author_facet Hassan, Rubayet
Cesmeci, Sevki
Baniasadi, Mahmoud
Palacio, Anthony
Robbins, Austin
author_sort Hassan, Rubayet
collection PubMed
description In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed with the previously published data in the literature to ensure the accuracy of the simulations. The proposed optimum duckbill valve micropump can pump 2.45 µL of fluid during the first 1 s, including both contraction and expansion phases, almost 16.67% more than the basic model. In addition, the model can pump a maximum volume of 0.26 µL of fluid at the end of the contraction phase (at 0.5 s) when the magnetic flux density is at maximum (0.027 T). The use of a duckbill valve in the model also reduces the backflow by almost 7.5 times more than the model without any valve. The proposed device could potentially be used in a broad range of applications, such as an insulin dosing system for Type 1 diabetic patients, artificial organs to transport blood, organ-on-chip applications, and so on.
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spelling pubmed-91469402022-05-29 A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications Hassan, Rubayet Cesmeci, Sevki Baniasadi, Mahmoud Palacio, Anthony Robbins, Austin Micromachines (Basel) Article In this study, we propose a duckbill valve microfluidic pump that relies on an electromagnetic actuation mechanism. An FEA/CFD-based approach was adopted for the design of the device due to the coupled electromagnetic–solid–fluid interactions in the device. The simulation methodology was confirmed with the previously published data in the literature to ensure the accuracy of the simulations. The proposed optimum duckbill valve micropump can pump 2.45 µL of fluid during the first 1 s, including both contraction and expansion phases, almost 16.67% more than the basic model. In addition, the model can pump a maximum volume of 0.26 µL of fluid at the end of the contraction phase (at 0.5 s) when the magnetic flux density is at maximum (0.027 T). The use of a duckbill valve in the model also reduces the backflow by almost 7.5 times more than the model without any valve. The proposed device could potentially be used in a broad range of applications, such as an insulin dosing system for Type 1 diabetic patients, artificial organs to transport blood, organ-on-chip applications, and so on. MDPI 2022-04-30 /pmc/articles/PMC9146940/ /pubmed/35630190 http://dx.doi.org/10.3390/mi13050723 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hassan, Rubayet
Cesmeci, Sevki
Baniasadi, Mahmoud
Palacio, Anthony
Robbins, Austin
A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title_full A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title_fullStr A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title_full_unstemmed A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title_short A Magnetorheological Duckbill Valve Micropump for Drug Delivery Applications
title_sort magnetorheological duckbill valve micropump for drug delivery applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146940/
https://www.ncbi.nlm.nih.gov/pubmed/35630190
http://dx.doi.org/10.3390/mi13050723
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