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Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity

Cardiac fibrosis is the basis of structural and functional disorders in patients with diabetes mellitus (T2DM). A wide range of laboratory and instrumental methods is used for its prediction. The study aimed to identify simple predictors of cardiac fibrosis in patients with T2DM based on the analysi...

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Autores principales: Luneva, Ekaterina B., Vasileva, Anastasia A., Karelkina, Elena V., Boyarinova, Maria A., Mikhaylov, Evgeny N., Ryzhkov, Anton V., Babenko, Alina Y., Konradi, Alexandra O., Moiseeva, Olga M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147134/
https://www.ncbi.nlm.nih.gov/pubmed/35628969
http://dx.doi.org/10.3390/jcm11102843
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author Luneva, Ekaterina B.
Vasileva, Anastasia A.
Karelkina, Elena V.
Boyarinova, Maria A.
Mikhaylov, Evgeny N.
Ryzhkov, Anton V.
Babenko, Alina Y.
Konradi, Alexandra O.
Moiseeva, Olga M.
author_facet Luneva, Ekaterina B.
Vasileva, Anastasia A.
Karelkina, Elena V.
Boyarinova, Maria A.
Mikhaylov, Evgeny N.
Ryzhkov, Anton V.
Babenko, Alina Y.
Konradi, Alexandra O.
Moiseeva, Olga M.
author_sort Luneva, Ekaterina B.
collection PubMed
description Cardiac fibrosis is the basis of structural and functional disorders in patients with diabetes mellitus (T2DM). A wide range of laboratory and instrumental methods is used for its prediction. The study aimed to identify simple predictors of cardiac fibrosis in patients with T2DM based on the analysis of circulating fibrosis biomarkers and arterial stiffness. The study included patients with T2DM (n = 37) and cardiovascular risk factors (RF, n = 27) who underwent ECHO, cardiac magnetic resonance imaging (MRI), pulse wave analysis (PWV), reactive hyperemia (RH), peripheral arterial tonometry, carotid ultrasonography, and assessment of serum fibrosis biomarkers. As a control group, 15 healthy subjects were examined. Left ventricular concentric hypertrophy was accompanied by an increased serum galectin-3 level in T2DM patients. There was a relationship between the PICP and HbA1c levels in both main groups (R2 = 0.309; p = 0.014). A negative correlation between PICP level and the global longitudinal strain (GLS) was found (r = −0.467; p = 0.004). The RH index had a negative correlation with the duration of diabetes (r = −0.356; p = 0.03), the carotid-femoral PWV (r = −0.371; p = 0.024), and the carotid intima-media thickness (r = −0.622; p < 0.001). The late gadolinium-enhanced (LGE) cardiac MRI was detected in 22 (59.5%) T2DM and in 4 (14.85%) RF patients. Diabetes, its baseline treatment with metformin, HbA1c and serum TIMP-1 levels, and left ventricle hypertrophy had moderate positive correlations with LGE findings (p < 0.05). Using the multivariate regression analysis, increased TIMP-1 level was identified as an independent factor associated with cardiac fibrosis.
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spelling pubmed-91471342022-05-29 Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity Luneva, Ekaterina B. Vasileva, Anastasia A. Karelkina, Elena V. Boyarinova, Maria A. Mikhaylov, Evgeny N. Ryzhkov, Anton V. Babenko, Alina Y. Konradi, Alexandra O. Moiseeva, Olga M. J Clin Med Article Cardiac fibrosis is the basis of structural and functional disorders in patients with diabetes mellitus (T2DM). A wide range of laboratory and instrumental methods is used for its prediction. The study aimed to identify simple predictors of cardiac fibrosis in patients with T2DM based on the analysis of circulating fibrosis biomarkers and arterial stiffness. The study included patients with T2DM (n = 37) and cardiovascular risk factors (RF, n = 27) who underwent ECHO, cardiac magnetic resonance imaging (MRI), pulse wave analysis (PWV), reactive hyperemia (RH), peripheral arterial tonometry, carotid ultrasonography, and assessment of serum fibrosis biomarkers. As a control group, 15 healthy subjects were examined. Left ventricular concentric hypertrophy was accompanied by an increased serum galectin-3 level in T2DM patients. There was a relationship between the PICP and HbA1c levels in both main groups (R2 = 0.309; p = 0.014). A negative correlation between PICP level and the global longitudinal strain (GLS) was found (r = −0.467; p = 0.004). The RH index had a negative correlation with the duration of diabetes (r = −0.356; p = 0.03), the carotid-femoral PWV (r = −0.371; p = 0.024), and the carotid intima-media thickness (r = −0.622; p < 0.001). The late gadolinium-enhanced (LGE) cardiac MRI was detected in 22 (59.5%) T2DM and in 4 (14.85%) RF patients. Diabetes, its baseline treatment with metformin, HbA1c and serum TIMP-1 levels, and left ventricle hypertrophy had moderate positive correlations with LGE findings (p < 0.05). Using the multivariate regression analysis, increased TIMP-1 level was identified as an independent factor associated with cardiac fibrosis. MDPI 2022-05-18 /pmc/articles/PMC9147134/ /pubmed/35628969 http://dx.doi.org/10.3390/jcm11102843 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luneva, Ekaterina B.
Vasileva, Anastasia A.
Karelkina, Elena V.
Boyarinova, Maria A.
Mikhaylov, Evgeny N.
Ryzhkov, Anton V.
Babenko, Alina Y.
Konradi, Alexandra O.
Moiseeva, Olga M.
Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title_full Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title_fullStr Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title_full_unstemmed Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title_short Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity
title_sort simple predictors for cardiac fibrosis in patients with type 2 diabetes mellitus: the role of circulating biomarkers and pulse wave velocity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147134/
https://www.ncbi.nlm.nih.gov/pubmed/35628969
http://dx.doi.org/10.3390/jcm11102843
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