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Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort

Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering the analysis of AbR kinetics. We present the ORCHESTRA SOT recipients cohort assessed for AbR at first dose (t0), second dose (t1), an...

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Autores principales: Giannella, Maddalena, Righi, Elda, Pascale, Renato, Rinaldi, Matteo, Caroccia, Natascia, Gamberini, Chiara, Palacios-Baena, Zaira R., Caponcello, Giulia, Morelli, Maria Cristina, Tamè, Mariarosa, Busutti, Marco, Comai, Giorgia, Potena, Luciano, Salvaterra, Elena, Feltrin, Giuseppe, Cillo, Umberto, Gerosa, Gino, Cananzi, Mara, Piano, Salvatore, Benetti, Elisa, Burra, Patrizia, Loy, Monica, Furian, Lucrezia, Zaza, Gianluigi, Onorati, Francesco, Carraro, Amedeo, Gastaldon, Fiorella, Nordio, Maurizio, Kumar-Singh, Samir, Abedini, Mahsa, Boffetta, Paolo, Rodríguez-Baño, Jesús, Lazzarotto, Tiziana, Viale, Pierluigi, Tacconelli, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147204/
https://www.ncbi.nlm.nih.gov/pubmed/35630462
http://dx.doi.org/10.3390/microorganisms10051021
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author Giannella, Maddalena
Righi, Elda
Pascale, Renato
Rinaldi, Matteo
Caroccia, Natascia
Gamberini, Chiara
Palacios-Baena, Zaira R.
Caponcello, Giulia
Morelli, Maria Cristina
Tamè, Mariarosa
Busutti, Marco
Comai, Giorgia
Potena, Luciano
Salvaterra, Elena
Feltrin, Giuseppe
Cillo, Umberto
Gerosa, Gino
Cananzi, Mara
Piano, Salvatore
Benetti, Elisa
Burra, Patrizia
Loy, Monica
Furian, Lucrezia
Zaza, Gianluigi
Onorati, Francesco
Carraro, Amedeo
Gastaldon, Fiorella
Nordio, Maurizio
Kumar-Singh, Samir
Abedini, Mahsa
Boffetta, Paolo
Rodríguez-Baño, Jesús
Lazzarotto, Tiziana
Viale, Pierluigi
Tacconelli, Evelina
author_facet Giannella, Maddalena
Righi, Elda
Pascale, Renato
Rinaldi, Matteo
Caroccia, Natascia
Gamberini, Chiara
Palacios-Baena, Zaira R.
Caponcello, Giulia
Morelli, Maria Cristina
Tamè, Mariarosa
Busutti, Marco
Comai, Giorgia
Potena, Luciano
Salvaterra, Elena
Feltrin, Giuseppe
Cillo, Umberto
Gerosa, Gino
Cananzi, Mara
Piano, Salvatore
Benetti, Elisa
Burra, Patrizia
Loy, Monica
Furian, Lucrezia
Zaza, Gianluigi
Onorati, Francesco
Carraro, Amedeo
Gastaldon, Fiorella
Nordio, Maurizio
Kumar-Singh, Samir
Abedini, Mahsa
Boffetta, Paolo
Rodríguez-Baño, Jesús
Lazzarotto, Tiziana
Viale, Pierluigi
Tacconelli, Evelina
author_sort Giannella, Maddalena
collection PubMed
description Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering the analysis of AbR kinetics. We present the ORCHESTRA SOT recipients cohort assessed for AbR at first dose (t0), second dose (t1), and within 3 ± 1 month (t2) after the first dose. We analyzed 1062 SOT patients (kidney, 63.7%; liver, 17.4%; heart, 16.7%; and lung, 2.5%) and 5045 health care workers (HCWs). The AbR rates in the SOTs and HCWs were 52.3% and 99.4%. The antibody levels were significantly higher in the HCWs than in the SOTs (p < 0.001). The kinetics showed an increase (p < 0.001) in antibody levels up to 76 days and a non-significant decrease after 118 days in the SOT recipients versus a decrease up to 76 days (p = 0.02) and a less pronounced decrease between 76 and 118 days (p = 0.04) in the HCWs. Upon multivariable analysis, liver transplant, ≥3 years from SOT, mRNA-1273, azathioprine, and longer time from t0 were associated with a positive AbR at t2. Older age, other comorbidities, mycophenolate, steroids, and impaired graft function were associated with lower AbR probability. Our results may be useful to optimize strategies of immune monitoring after COVID-19 vaccination and indications regarding timing for booster dosages calibrated on SOT patients’ characteristics.
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spelling pubmed-91472042022-05-29 Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort Giannella, Maddalena Righi, Elda Pascale, Renato Rinaldi, Matteo Caroccia, Natascia Gamberini, Chiara Palacios-Baena, Zaira R. Caponcello, Giulia Morelli, Maria Cristina Tamè, Mariarosa Busutti, Marco Comai, Giorgia Potena, Luciano Salvaterra, Elena Feltrin, Giuseppe Cillo, Umberto Gerosa, Gino Cananzi, Mara Piano, Salvatore Benetti, Elisa Burra, Patrizia Loy, Monica Furian, Lucrezia Zaza, Gianluigi Onorati, Francesco Carraro, Amedeo Gastaldon, Fiorella Nordio, Maurizio Kumar-Singh, Samir Abedini, Mahsa Boffetta, Paolo Rodríguez-Baño, Jesús Lazzarotto, Tiziana Viale, Pierluigi Tacconelli, Evelina Microorganisms Article Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering the analysis of AbR kinetics. We present the ORCHESTRA SOT recipients cohort assessed for AbR at first dose (t0), second dose (t1), and within 3 ± 1 month (t2) after the first dose. We analyzed 1062 SOT patients (kidney, 63.7%; liver, 17.4%; heart, 16.7%; and lung, 2.5%) and 5045 health care workers (HCWs). The AbR rates in the SOTs and HCWs were 52.3% and 99.4%. The antibody levels were significantly higher in the HCWs than in the SOTs (p < 0.001). The kinetics showed an increase (p < 0.001) in antibody levels up to 76 days and a non-significant decrease after 118 days in the SOT recipients versus a decrease up to 76 days (p = 0.02) and a less pronounced decrease between 76 and 118 days (p = 0.04) in the HCWs. Upon multivariable analysis, liver transplant, ≥3 years from SOT, mRNA-1273, azathioprine, and longer time from t0 were associated with a positive AbR at t2. Older age, other comorbidities, mycophenolate, steroids, and impaired graft function were associated with lower AbR probability. Our results may be useful to optimize strategies of immune monitoring after COVID-19 vaccination and indications regarding timing for booster dosages calibrated on SOT patients’ characteristics. MDPI 2022-05-12 /pmc/articles/PMC9147204/ /pubmed/35630462 http://dx.doi.org/10.3390/microorganisms10051021 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Giannella, Maddalena
Righi, Elda
Pascale, Renato
Rinaldi, Matteo
Caroccia, Natascia
Gamberini, Chiara
Palacios-Baena, Zaira R.
Caponcello, Giulia
Morelli, Maria Cristina
Tamè, Mariarosa
Busutti, Marco
Comai, Giorgia
Potena, Luciano
Salvaterra, Elena
Feltrin, Giuseppe
Cillo, Umberto
Gerosa, Gino
Cananzi, Mara
Piano, Salvatore
Benetti, Elisa
Burra, Patrizia
Loy, Monica
Furian, Lucrezia
Zaza, Gianluigi
Onorati, Francesco
Carraro, Amedeo
Gastaldon, Fiorella
Nordio, Maurizio
Kumar-Singh, Samir
Abedini, Mahsa
Boffetta, Paolo
Rodríguez-Baño, Jesús
Lazzarotto, Tiziana
Viale, Pierluigi
Tacconelli, Evelina
Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title_full Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title_fullStr Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title_full_unstemmed Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title_short Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
title_sort evaluation of the kinetics of antibody response to covid-19 vaccine in solid organ transplant recipients: the prospective multicenter orchestra cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147204/
https://www.ncbi.nlm.nih.gov/pubmed/35630462
http://dx.doi.org/10.3390/microorganisms10051021
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