Molecular Dynamics Simulations Reveal Structural Interconnections within Sec14-PH Bipartite Domain from Human Neurofibromin

Neurofibromin, the main RasGAP in the nervous system, is a 2818 aa protein with several poorly characterized functional domains. Mutations in the NF1-encoding gene lead to an autosomal dominant syndrome, neurofibromatosis, with an incidence of 1 out of 3000 newborns. Missense mutations spread in the...

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Detalles Bibliográficos
Autores principales: Rizza, Fabio, Vertemara, Jacopo, Tisi, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147397/
https://www.ncbi.nlm.nih.gov/pubmed/35628517
http://dx.doi.org/10.3390/ijms23105707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147397/
https://www.ncbi.nlm.nih.gov/pubmed/35628517
http://dx.doi.org/10.3390/ijms23105707

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