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Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats

This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make c...

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Autores principales: Bychkov, Aleksey, Koptev, Vyacheslav, Zaharova, Varvara, Reshetnikova, Polina, Trofimova, Elena, Bychkova, Elena, Podgorbunskikh, Ekaterina, Lomovsky, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147437/
https://www.ncbi.nlm.nih.gov/pubmed/35631133
http://dx.doi.org/10.3390/nu14101992
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author Bychkov, Aleksey
Koptev, Vyacheslav
Zaharova, Varvara
Reshetnikova, Polina
Trofimova, Elena
Bychkova, Elena
Podgorbunskikh, Ekaterina
Lomovsky, Oleg
author_facet Bychkov, Aleksey
Koptev, Vyacheslav
Zaharova, Varvara
Reshetnikova, Polina
Trofimova, Elena
Bychkova, Elena
Podgorbunskikh, Ekaterina
Lomovsky, Oleg
author_sort Bychkov, Aleksey
collection PubMed
description This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).
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spelling pubmed-91474372022-05-29 Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats Bychkov, Aleksey Koptev, Vyacheslav Zaharova, Varvara Reshetnikova, Polina Trofimova, Elena Bychkova, Elena Podgorbunskikh, Ekaterina Lomovsky, Oleg Nutrients Article This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts). MDPI 2022-05-10 /pmc/articles/PMC9147437/ /pubmed/35631133 http://dx.doi.org/10.3390/nu14101992 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bychkov, Aleksey
Koptev, Vyacheslav
Zaharova, Varvara
Reshetnikova, Polina
Trofimova, Elena
Bychkova, Elena
Podgorbunskikh, Ekaterina
Lomovsky, Oleg
Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title_full Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title_fullStr Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title_full_unstemmed Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title_short Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
title_sort experimental testing of the action of vitamin d and silicon chelates in bone fracture healing and bone turnover in mice and rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147437/
https://www.ncbi.nlm.nih.gov/pubmed/35631133
http://dx.doi.org/10.3390/nu14101992
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