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Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifunga...

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Autores principales: Ito, Yuya, Takazono, Takahiro, Obase, Yasushi, Fukahori, Susumu, Ashizawa, Nobuyuki, Hirayama, Tatsuro, Tashiro, Masato, Yamamoto, Kazuko, Imamura, Yoshifumi, Hosogaya, Naoki, Fukushima, Chizu, Morinaga, Yoshitomo, Yanagihara, Katsunori, Izumikawa, Koichi, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147526/
https://www.ncbi.nlm.nih.gov/pubmed/35628692
http://dx.doi.org/10.3390/jof8050436
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author Ito, Yuya
Takazono, Takahiro
Obase, Yasushi
Fukahori, Susumu
Ashizawa, Nobuyuki
Hirayama, Tatsuro
Tashiro, Masato
Yamamoto, Kazuko
Imamura, Yoshifumi
Hosogaya, Naoki
Fukushima, Chizu
Morinaga, Yoshitomo
Yanagihara, Katsunori
Izumikawa, Koichi
Mukae, Hiroshi
author_facet Ito, Yuya
Takazono, Takahiro
Obase, Yasushi
Fukahori, Susumu
Ashizawa, Nobuyuki
Hirayama, Tatsuro
Tashiro, Masato
Yamamoto, Kazuko
Imamura, Yoshifumi
Hosogaya, Naoki
Fukushima, Chizu
Morinaga, Yoshitomo
Yanagihara, Katsunori
Izumikawa, Koichi
Mukae, Hiroshi
author_sort Ito, Yuya
collection PubMed
description Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifungals are required. In this study, we investigated whether the serum cytokine profile is useful for understanding the pathology and for differentiating between these diseases. We compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA at Nagasaki University Hospital between January 2003 and December 2018. In total, 14 healthy subjects, 19 patients with asthma, 11 with ABPA, and 10 with CPA were enrolled. Interleukin (IL) -5 levels were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor (TNF) levels were significantly higher in patients with CPA than in those with asthma (p < 0.05, Dunn’s multiple comparison test). The sensitivity and specificity of the IL-10/IL-5 ratio (cutoff index 2.47) for diagnosing CPA were 70% and 100%, respectively. The serum cytokine profile is useful in understanding the pathology of ABPA and CPA, and the IL-10/IL-5 ratio may be a novel supplemental biomarker for indicating the pathology of CPA.
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spelling pubmed-91475262022-05-29 Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis Ito, Yuya Takazono, Takahiro Obase, Yasushi Fukahori, Susumu Ashizawa, Nobuyuki Hirayama, Tatsuro Tashiro, Masato Yamamoto, Kazuko Imamura, Yoshifumi Hosogaya, Naoki Fukushima, Chizu Morinaga, Yoshitomo Yanagihara, Katsunori Izumikawa, Koichi Mukae, Hiroshi J Fungi (Basel) Article Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifungals are required. In this study, we investigated whether the serum cytokine profile is useful for understanding the pathology and for differentiating between these diseases. We compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA at Nagasaki University Hospital between January 2003 and December 2018. In total, 14 healthy subjects, 19 patients with asthma, 11 with ABPA, and 10 with CPA were enrolled. Interleukin (IL) -5 levels were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor (TNF) levels were significantly higher in patients with CPA than in those with asthma (p < 0.05, Dunn’s multiple comparison test). The sensitivity and specificity of the IL-10/IL-5 ratio (cutoff index 2.47) for diagnosing CPA were 70% and 100%, respectively. The serum cytokine profile is useful in understanding the pathology of ABPA and CPA, and the IL-10/IL-5 ratio may be a novel supplemental biomarker for indicating the pathology of CPA. MDPI 2022-04-23 /pmc/articles/PMC9147526/ /pubmed/35628692 http://dx.doi.org/10.3390/jof8050436 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ito, Yuya
Takazono, Takahiro
Obase, Yasushi
Fukahori, Susumu
Ashizawa, Nobuyuki
Hirayama, Tatsuro
Tashiro, Masato
Yamamoto, Kazuko
Imamura, Yoshifumi
Hosogaya, Naoki
Fukushima, Chizu
Morinaga, Yoshitomo
Yanagihara, Katsunori
Izumikawa, Koichi
Mukae, Hiroshi
Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title_full Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title_fullStr Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title_full_unstemmed Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title_short Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis
title_sort serum cytokines usefulness for understanding the pathology in allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147526/
https://www.ncbi.nlm.nih.gov/pubmed/35628692
http://dx.doi.org/10.3390/jof8050436
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