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Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project

The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 9...

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Autores principales: Avdeev, Sergey, Rachina, Svetlana, Belkova, Yuliya, Kozlov, Roman, Versporten, Ann, Pauwels, Ines, Goossens, Herman, Bochanova, Elena, Elokhina, Elena, Portnjagina, Ulyana, Reshetko, Olga, Sychev, Igor, Strelkova, Darya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147532/
https://www.ncbi.nlm.nih.gov/pubmed/35622702
http://dx.doi.org/10.3390/tropicalmed7050075
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author Avdeev, Sergey
Rachina, Svetlana
Belkova, Yuliya
Kozlov, Roman
Versporten, Ann
Pauwels, Ines
Goossens, Herman
Bochanova, Elena
Elokhina, Elena
Portnjagina, Ulyana
Reshetko, Olga
Sychev, Igor
Strelkova, Darya
author_facet Avdeev, Sergey
Rachina, Svetlana
Belkova, Yuliya
Kozlov, Roman
Versporten, Ann
Pauwels, Ines
Goossens, Herman
Bochanova, Elena
Elokhina, Elena
Portnjagina, Ulyana
Reshetko, Olga
Sychev, Igor
Strelkova, Darya
author_sort Avdeev, Sergey
collection PubMed
description The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 999 patients in COVID-19 wards in six hospitals surveyed in 2021, 51.3% received antimicrobials (79% in intensive care, 47.5% in medical wards). Systemic antivirals and antibiotics were prescribed to 31% and 35.1% of patients, respectively, and a combination of both to 14.1% of patients. The top antivirals administered were favipiravir (65%), remdesivir (19.2%), and umifenovir (15.8%); the top antibiotics were ceftriaxone (29.7%), levofloxacin (18%), and cefoperazone/sulbactam (10.4%). The vast majority of antibiotics was prescribed for treatment of pneumonia or COVID-19 infection (59.3% and 25.1%, respectively). Treatment was based on biomarker data in 42.7% of patients but was targeted only in 29.6% (6.7% for antibiotics). The rate of non-compliance with guidelines reached 16.6%. Antimicrobial prescribing patterns varied considerably in COVID-19 wards in Russian hospitals with groundlessly high rates of systemic antibiotics. Antimicrobial usage surveillance and stewardship should be applied to inpatient care during the COVID-19 pandemic.
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spelling pubmed-91475322022-05-29 Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project Avdeev, Sergey Rachina, Svetlana Belkova, Yuliya Kozlov, Roman Versporten, Ann Pauwels, Ines Goossens, Herman Bochanova, Elena Elokhina, Elena Portnjagina, Ulyana Reshetko, Olga Sychev, Igor Strelkova, Darya Trop Med Infect Dis Article The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 999 patients in COVID-19 wards in six hospitals surveyed in 2021, 51.3% received antimicrobials (79% in intensive care, 47.5% in medical wards). Systemic antivirals and antibiotics were prescribed to 31% and 35.1% of patients, respectively, and a combination of both to 14.1% of patients. The top antivirals administered were favipiravir (65%), remdesivir (19.2%), and umifenovir (15.8%); the top antibiotics were ceftriaxone (29.7%), levofloxacin (18%), and cefoperazone/sulbactam (10.4%). The vast majority of antibiotics was prescribed for treatment of pneumonia or COVID-19 infection (59.3% and 25.1%, respectively). Treatment was based on biomarker data in 42.7% of patients but was targeted only in 29.6% (6.7% for antibiotics). The rate of non-compliance with guidelines reached 16.6%. Antimicrobial prescribing patterns varied considerably in COVID-19 wards in Russian hospitals with groundlessly high rates of systemic antibiotics. Antimicrobial usage surveillance and stewardship should be applied to inpatient care during the COVID-19 pandemic. MDPI 2022-05-16 /pmc/articles/PMC9147532/ /pubmed/35622702 http://dx.doi.org/10.3390/tropicalmed7050075 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avdeev, Sergey
Rachina, Svetlana
Belkova, Yuliya
Kozlov, Roman
Versporten, Ann
Pauwels, Ines
Goossens, Herman
Bochanova, Elena
Elokhina, Elena
Portnjagina, Ulyana
Reshetko, Olga
Sychev, Igor
Strelkova, Darya
Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title_full Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title_fullStr Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title_full_unstemmed Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title_short Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
title_sort antimicrobial prescribing patterns in patients with covid-19 in russian multi-field hospitals in 2021: results of the global-pps project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147532/
https://www.ncbi.nlm.nih.gov/pubmed/35622702
http://dx.doi.org/10.3390/tropicalmed7050075
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