A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles

A new effective method for the synthesis of imidazo[1,5-b]pyridazines derivatives (yields = 68–89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed. The course of reaction has been examined by classical...

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Detalles Bibliográficos
Autores principales: Vandyshev, Dmitrii Yu., Burov, Oleg N., Lisovin, Anton V., Mangusheva, Daria A., Potapov, Mikhail A., Ilyinova, Tatiana N., Shikhaliev, Khidmet S., Geronikaki, Athina, Spinelli, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147549/
https://www.ncbi.nlm.nih.gov/pubmed/35630803
http://dx.doi.org/10.3390/molecules27103326
Descripción
Sumario:A new effective method for the synthesis of imidazo[1,5-b]pyridazines derivatives (yields = 68–89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed. The course of reaction has been examined by classical organic methods, HPLC-MS analysis, and quantum-chemical calculations.

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