Cargando…

The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy

Dexmedetomidine has sedative, sympatholytic, analgesic, and anti-inflammatory effects. We investigated the effects of intraoperative dexmedetomidine infusion without a loading dose in the prevention of pain and inflammation after laparoscopic hysterectomy. In this study, 100 patients undergoing lapa...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jiyoung, Hwang, He Won, Jeong, Ju-Yeon, Kim, Yong Min, Park, Chunghyun, Kim, Jong Yeop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147550/
https://www.ncbi.nlm.nih.gov/pubmed/35628926
http://dx.doi.org/10.3390/jcm11102802
_version_ 1784716835175792640
author Lee, Jiyoung
Hwang, He Won
Jeong, Ju-Yeon
Kim, Yong Min
Park, Chunghyun
Kim, Jong Yeop
author_facet Lee, Jiyoung
Hwang, He Won
Jeong, Ju-Yeon
Kim, Yong Min
Park, Chunghyun
Kim, Jong Yeop
author_sort Lee, Jiyoung
collection PubMed
description Dexmedetomidine has sedative, sympatholytic, analgesic, and anti-inflammatory effects. We investigated the effects of intraoperative dexmedetomidine infusion without a loading dose in the prevention of pain and inflammation after laparoscopic hysterectomy. In this study, 100 patients undergoing laparoscopic hysterectomy under desflurane anesthesia were randomized to receive either 0.9% saline or dexmedetomidine (0.4 μg/kg/h) after induction to trocar removal. The primary endpoints were postoperative pain and inflammatory response presented by the level of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-10, and C-reactive protein (CRP). The secondary endpoints were hemodynamics during the anesthesia and surgery and postoperative nausea and vomiting. Postoperative pain was decreased in the dexmedetomidine group for every time point, and post-anesthesia care unit (PACU) rescue fentanyl doses were decreased in the dexmedetomidine group. The inflammatory response representing TNF-α, IL-6, IL-10, and CRP were similar across the two groups. Postoperative nausea and vomiting from PACU discharge to 24 h post-surgery were reduced in the dexmedetomidine group. During anesthesia and surgery, the patient’s heart rate was maintained lower in the dexmedetomidine-receiving group. Dexmedetomidine of 0.4 μg/kg/h given as an intraoperative infusion significantly reduced postoperative pain but did not reduce the inflammatory responses in patients undergoing laparoscopic hysterectomy.
format Online
Article
Text
id pubmed-9147550
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91475502022-05-29 The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy Lee, Jiyoung Hwang, He Won Jeong, Ju-Yeon Kim, Yong Min Park, Chunghyun Kim, Jong Yeop J Clin Med Article Dexmedetomidine has sedative, sympatholytic, analgesic, and anti-inflammatory effects. We investigated the effects of intraoperative dexmedetomidine infusion without a loading dose in the prevention of pain and inflammation after laparoscopic hysterectomy. In this study, 100 patients undergoing laparoscopic hysterectomy under desflurane anesthesia were randomized to receive either 0.9% saline or dexmedetomidine (0.4 μg/kg/h) after induction to trocar removal. The primary endpoints were postoperative pain and inflammatory response presented by the level of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-10, and C-reactive protein (CRP). The secondary endpoints were hemodynamics during the anesthesia and surgery and postoperative nausea and vomiting. Postoperative pain was decreased in the dexmedetomidine group for every time point, and post-anesthesia care unit (PACU) rescue fentanyl doses were decreased in the dexmedetomidine group. The inflammatory response representing TNF-α, IL-6, IL-10, and CRP were similar across the two groups. Postoperative nausea and vomiting from PACU discharge to 24 h post-surgery were reduced in the dexmedetomidine group. During anesthesia and surgery, the patient’s heart rate was maintained lower in the dexmedetomidine-receiving group. Dexmedetomidine of 0.4 μg/kg/h given as an intraoperative infusion significantly reduced postoperative pain but did not reduce the inflammatory responses in patients undergoing laparoscopic hysterectomy. MDPI 2022-05-16 /pmc/articles/PMC9147550/ /pubmed/35628926 http://dx.doi.org/10.3390/jcm11102802 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Jiyoung
Hwang, He Won
Jeong, Ju-Yeon
Kim, Yong Min
Park, Chunghyun
Kim, Jong Yeop
The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title_full The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title_fullStr The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title_full_unstemmed The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title_short The Effect of Low-Dose Dexmedetomidine on Pain and Inflammation in Patients Undergoing Laparoscopic Hysterectomy
title_sort effect of low-dose dexmedetomidine on pain and inflammation in patients undergoing laparoscopic hysterectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147550/
https://www.ncbi.nlm.nih.gov/pubmed/35628926
http://dx.doi.org/10.3390/jcm11102802
work_keys_str_mv AT leejiyoung theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT hwanghewon theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT jeongjuyeon theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT kimyongmin theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT parkchunghyun theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT kimjongyeop theeffectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT leejiyoung effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT hwanghewon effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT jeongjuyeon effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT kimyongmin effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT parkchunghyun effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy
AT kimjongyeop effectoflowdosedexmedetomidineonpainandinflammationinpatientsundergoinglaparoscopichysterectomy