Two Innovative Approaches to Optimize Vancomycin Dosing Using Estimated AUC after First Dose: Validation Using Data Generated from Population PK Model Coupled with Monte-Carlo Simulation and Comparison with the First-Order PK Equation Approach

The revised consensus guidelines for optimizing vancomycin doses suggest that maintaining the area under the concentration-time curve to minimal inhibitory concentration ratio (AUC/MIC) of 400–600 mg·h/L is the target pharmacokinetic/pharmacodynamic (PK/PD) index for efficacy. AUC-guided dosing appr...

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Detalles Bibliográficos
Autores principales: Liu, Qingxia, Huang, Huiping, Xu, Baohua, Li, Dandan, Liu, Maobai, Shaik, Imam H., Wu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147553/
https://www.ncbi.nlm.nih.gov/pubmed/35631590
http://dx.doi.org/10.3390/pharmaceutics14051004

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