Cargando…
Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice
Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO(2)) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interact...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147568/ https://www.ncbi.nlm.nih.gov/pubmed/35630890 http://dx.doi.org/10.3390/nano12101669 |
_version_ | 1784716839467614208 |
---|---|
author | Sitia, Giovanni Fiordaliso, Fabio Violatto, Martina B. Alarcon, Jennifer Fernandez Talamini, Laura Corbelli, Alessandro Ferreira, Lorena Maria Tran, Ngoc Lan Chakraborty, Indranath Salmona, Mario Parak, Wolfgang J. Diomede, Luisa Bigini, Paolo |
author_facet | Sitia, Giovanni Fiordaliso, Fabio Violatto, Martina B. Alarcon, Jennifer Fernandez Talamini, Laura Corbelli, Alessandro Ferreira, Lorena Maria Tran, Ngoc Lan Chakraborty, Indranath Salmona, Mario Parak, Wolfgang J. Diomede, Luisa Bigini, Paolo |
author_sort | Sitia, Giovanni |
collection | PubMed |
description | Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO(2)) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interaction with biological targets is still far from clear. We evaluated the impact of acute E171 administration on invertebrate and vertebrate animals. In the nematode, Caenorhabditis elegans, the administration of up to 1.0 mg/mL of E171 did not affect the worm’s viability and lifespan, but significantly impaired its pharyngeal function, reproduction, and development. We also investigated whether the intravenous administration of E171 in mice (at the dose of 6 mg/kg/body weight) could result in an acute over-absorption of filter organs. A significant increase of hepatic titanium concentration and the formation of microgranulomas were observed. Interstitial inflammation and parenchymal modification were found in the lungs, coupled with titanium accumulation. This was probably due to the propensity of TiO(2) NPs to agglomerate, as demonstrated by transmission electron microscopy experiments showing that the incubation of E171 with serum promoted the formation of compact clusters. Overall, these data emphasize the actual risk for human and animal exposure to E171. |
format | Online Article Text |
id | pubmed-9147568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91475682022-05-29 Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice Sitia, Giovanni Fiordaliso, Fabio Violatto, Martina B. Alarcon, Jennifer Fernandez Talamini, Laura Corbelli, Alessandro Ferreira, Lorena Maria Tran, Ngoc Lan Chakraborty, Indranath Salmona, Mario Parak, Wolfgang J. Diomede, Luisa Bigini, Paolo Nanomaterials (Basel) Article Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO(2)) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interaction with biological targets is still far from clear. We evaluated the impact of acute E171 administration on invertebrate and vertebrate animals. In the nematode, Caenorhabditis elegans, the administration of up to 1.0 mg/mL of E171 did not affect the worm’s viability and lifespan, but significantly impaired its pharyngeal function, reproduction, and development. We also investigated whether the intravenous administration of E171 in mice (at the dose of 6 mg/kg/body weight) could result in an acute over-absorption of filter organs. A significant increase of hepatic titanium concentration and the formation of microgranulomas were observed. Interstitial inflammation and parenchymal modification were found in the lungs, coupled with titanium accumulation. This was probably due to the propensity of TiO(2) NPs to agglomerate, as demonstrated by transmission electron microscopy experiments showing that the incubation of E171 with serum promoted the formation of compact clusters. Overall, these data emphasize the actual risk for human and animal exposure to E171. MDPI 2022-05-13 /pmc/articles/PMC9147568/ /pubmed/35630890 http://dx.doi.org/10.3390/nano12101669 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sitia, Giovanni Fiordaliso, Fabio Violatto, Martina B. Alarcon, Jennifer Fernandez Talamini, Laura Corbelli, Alessandro Ferreira, Lorena Maria Tran, Ngoc Lan Chakraborty, Indranath Salmona, Mario Parak, Wolfgang J. Diomede, Luisa Bigini, Paolo Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title | Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title_full | Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title_fullStr | Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title_full_unstemmed | Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title_short | Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
title_sort | food-grade titanium dioxide induces toxicity in the nematode caenorhabditis elegans and acute hepatic and pulmonary responses in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147568/ https://www.ncbi.nlm.nih.gov/pubmed/35630890 http://dx.doi.org/10.3390/nano12101669 |
work_keys_str_mv | AT sitiagiovanni foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT fiordalisofabio foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT violattomartinab foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT alarconjenniferfernandez foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT talaminilaura foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT corbellialessandro foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT ferreiralorenamaria foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT tranngoclan foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT chakrabortyindranath foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT salmonamario foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT parakwolfgangj foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT diomedeluisa foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice AT biginipaolo foodgradetitaniumdioxideinducestoxicityinthenematodecaenorhabditiselegansandacutehepaticandpulmonaryresponsesinmice |