Hypoxia-Reoxygenation Impairs Autophagy-Lysosomal Machinery in Primary Human Trophoblasts Mimicking Placental Pathology of Early-Onset Preeclampsia

We have previously described that placental activation of autophagy is a central feature of normal pregnancy, whereas autophagy is impaired in preeclampsia (PE). Here, we show that hypoxia–reoxygenation (H/R) treatment dysregulates key molecules that maintain autophagy–lysosomal flux in primary huma...

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Detalles Bibliográficos
Autores principales: Cheng, Shibin, Huang, Zheping, Jash, Sukanta, Wu, Kathleen, Saito, Shigeru, Nakashima, Akitoshi, Sharma, Surendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147570/
https://www.ncbi.nlm.nih.gov/pubmed/35628454
http://dx.doi.org/10.3390/ijms23105644

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