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Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals

Adult morbid obesity is defined as abnormal or excessive fat accumulation, mostly resulting from a long-term unhealthy lifestyle. Between 10% and 30% of people with obesity exhibit low cardiometabolic risk. The metabolic syndrome has been suggested as an indicator of obesity-related metabolic dysreg...

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Autores principales: Pisoni, Serena, Marrachelli, Vannina G., Morales, Jose M., Maestrini, Sabrina, Di Blasio, Anna M., Monleón, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147578/
https://www.ncbi.nlm.nih.gov/pubmed/35629923
http://dx.doi.org/10.3390/metabo12050419
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author Pisoni, Serena
Marrachelli, Vannina G.
Morales, Jose M.
Maestrini, Sabrina
Di Blasio, Anna M.
Monleón, Daniel
author_facet Pisoni, Serena
Marrachelli, Vannina G.
Morales, Jose M.
Maestrini, Sabrina
Di Blasio, Anna M.
Monleón, Daniel
author_sort Pisoni, Serena
collection PubMed
description Adult morbid obesity is defined as abnormal or excessive fat accumulation, mostly resulting from a long-term unhealthy lifestyle. Between 10% and 30% of people with obesity exhibit low cardiometabolic risk. The metabolic syndrome has been suggested as an indicator of obesity-related metabolic dysregulation. Although the prevalence of obesity does not seem to be sex-related and metabolic syndrome occurs at all ages, in the last few years, sex-specific differences in the pathophysiology, diagnosis, and treatment of metabolic syndrome have received attention. The aim of this study was to determine the prevalence of metabolic syndrome and its components in different sex and age groups in people with metabolic unhealthy obesity and to compare them with people with metabolic healthy obesity. We analyzed the metabolome in 1350 well-phenotyped morbidly obese individuals and showed that there is a strong sex-dependent association of metabolic syndrome with circulating metabolites. Importantly, we demonstrated that metabolic dysregulation in women and men with severe obesity and metabolic syndrome is age-dependent. The metabolic profiles from our study showed age-dependent sex differences in the impact of MetS which are consistent with the cardiometabolic characterization. Although there is common ground for MetS in the metabolome of severe obesity, men older than 54 are affected in a more extensive and intensive manner. These findings strongly argue for more studies aimed at unraveling the mechanisms that underlie this sex-specific metabolic dysregulation in severe obesity. Moreover, these findings suggest that women and men might benefit from differential sex and age specific interventions to prevent the adverse cardiometabolic effects of severe obesity.
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spelling pubmed-91475782022-05-29 Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals Pisoni, Serena Marrachelli, Vannina G. Morales, Jose M. Maestrini, Sabrina Di Blasio, Anna M. Monleón, Daniel Metabolites Article Adult morbid obesity is defined as abnormal or excessive fat accumulation, mostly resulting from a long-term unhealthy lifestyle. Between 10% and 30% of people with obesity exhibit low cardiometabolic risk. The metabolic syndrome has been suggested as an indicator of obesity-related metabolic dysregulation. Although the prevalence of obesity does not seem to be sex-related and metabolic syndrome occurs at all ages, in the last few years, sex-specific differences in the pathophysiology, diagnosis, and treatment of metabolic syndrome have received attention. The aim of this study was to determine the prevalence of metabolic syndrome and its components in different sex and age groups in people with metabolic unhealthy obesity and to compare them with people with metabolic healthy obesity. We analyzed the metabolome in 1350 well-phenotyped morbidly obese individuals and showed that there is a strong sex-dependent association of metabolic syndrome with circulating metabolites. Importantly, we demonstrated that metabolic dysregulation in women and men with severe obesity and metabolic syndrome is age-dependent. The metabolic profiles from our study showed age-dependent sex differences in the impact of MetS which are consistent with the cardiometabolic characterization. Although there is common ground for MetS in the metabolome of severe obesity, men older than 54 are affected in a more extensive and intensive manner. These findings strongly argue for more studies aimed at unraveling the mechanisms that underlie this sex-specific metabolic dysregulation in severe obesity. Moreover, these findings suggest that women and men might benefit from differential sex and age specific interventions to prevent the adverse cardiometabolic effects of severe obesity. MDPI 2022-05-06 /pmc/articles/PMC9147578/ /pubmed/35629923 http://dx.doi.org/10.3390/metabo12050419 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pisoni, Serena
Marrachelli, Vannina G.
Morales, Jose M.
Maestrini, Sabrina
Di Blasio, Anna M.
Monleón, Daniel
Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title_full Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title_fullStr Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title_full_unstemmed Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title_short Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals
title_sort sex dimorphism in the metabolome of metabolic syndrome in morbidly obese individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147578/
https://www.ncbi.nlm.nih.gov/pubmed/35629923
http://dx.doi.org/10.3390/metabo12050419
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