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Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function
Background: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147607/ https://www.ncbi.nlm.nih.gov/pubmed/35629214 http://dx.doi.org/10.3390/jpm12050792 |
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author | Nakano, Tomoya Onoue, Kenji Terada, Chiyoko Terasaki, Satoshi Ishihara, Satomi Hashimoto, Yukihiro Nakada, Yasuki Nakagawa, Hitoshi Ueda, Tomoya Seno, Ayako Nishida, Taku Watanabe, Makoto Hoshii, Yoshinobu Hatakeyama, Kinta Sakaguchi, Yasuhiro Ohbayashi, Chiho Saito, Yoshihiko |
author_facet | Nakano, Tomoya Onoue, Kenji Terada, Chiyoko Terasaki, Satoshi Ishihara, Satomi Hashimoto, Yukihiro Nakada, Yasuki Nakagawa, Hitoshi Ueda, Tomoya Seno, Ayako Nishida, Taku Watanabe, Makoto Hoshii, Yoshinobu Hatakeyama, Kinta Sakaguchi, Yasuhiro Ohbayashi, Chiho Saito, Yoshihiko |
author_sort | Nakano, Tomoya |
collection | PubMed |
description | Background: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients. Methods: We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples. Results: The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiomyocyte area. The extent of TTR deposition was positively correlated with enlargement of the non-cardiomyocyte area, and these were positively correlated with LV diastolic dysfunction. Additionally, the extent of the area containing TTR was positively correlated with the percentage of cardiomyocyte nuclei stained for 8-hydroxy-2′deoxyguanosine, a marker of reactive oxygen species (ROS). ROS accumulation in cardiomyocytes was positively correlated with LV systolic dysfunction. Conclusion: Patients with ATTR-CM mainly displayed concentric LVH geometry. TTR amyloid deposition was associated with cardiac dysfunction via increased non-cardiomyocyte area and ROS accumulation in cardiomyocytes. |
format | Online Article Text |
id | pubmed-9147607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91476072022-05-29 Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function Nakano, Tomoya Onoue, Kenji Terada, Chiyoko Terasaki, Satoshi Ishihara, Satomi Hashimoto, Yukihiro Nakada, Yasuki Nakagawa, Hitoshi Ueda, Tomoya Seno, Ayako Nishida, Taku Watanabe, Makoto Hoshii, Yoshinobu Hatakeyama, Kinta Sakaguchi, Yasuhiro Ohbayashi, Chiho Saito, Yoshihiko J Pers Med Article Background: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients. Methods: We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples. Results: The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiomyocyte area. The extent of TTR deposition was positively correlated with enlargement of the non-cardiomyocyte area, and these were positively correlated with LV diastolic dysfunction. Additionally, the extent of the area containing TTR was positively correlated with the percentage of cardiomyocyte nuclei stained for 8-hydroxy-2′deoxyguanosine, a marker of reactive oxygen species (ROS). ROS accumulation in cardiomyocytes was positively correlated with LV systolic dysfunction. Conclusion: Patients with ATTR-CM mainly displayed concentric LVH geometry. TTR amyloid deposition was associated with cardiac dysfunction via increased non-cardiomyocyte area and ROS accumulation in cardiomyocytes. MDPI 2022-05-13 /pmc/articles/PMC9147607/ /pubmed/35629214 http://dx.doi.org/10.3390/jpm12050792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nakano, Tomoya Onoue, Kenji Terada, Chiyoko Terasaki, Satoshi Ishihara, Satomi Hashimoto, Yukihiro Nakada, Yasuki Nakagawa, Hitoshi Ueda, Tomoya Seno, Ayako Nishida, Taku Watanabe, Makoto Hoshii, Yoshinobu Hatakeyama, Kinta Sakaguchi, Yasuhiro Ohbayashi, Chiho Saito, Yoshihiko Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title | Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title_full | Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title_fullStr | Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title_full_unstemmed | Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title_short | Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function |
title_sort | transthyretin amyloid cardiomyopathy: impact of transthyretin amyloid deposition in myocardium on cardiac morphology and function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147607/ https://www.ncbi.nlm.nih.gov/pubmed/35629214 http://dx.doi.org/10.3390/jpm12050792 |
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