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Time Estimation of Polymer Translocation through Nano-Membrane
In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary name...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147610/ https://www.ncbi.nlm.nih.gov/pubmed/35631973 http://dx.doi.org/10.3390/polym14102090 |
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author | Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu |
author_facet | Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu |
author_sort | Paun, Maria-Alexandra |
collection | PubMed |
description | In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by P(x, t), as a macromolecular chain of lengthiness equal to x, to be able to pass by the nanopore in escape period t, was optimized. The longest-lasting likely escape time found with this model is indicated to be t(p) = 330 μs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature. |
format | Online Article Text |
id | pubmed-9147610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91476102022-05-29 Time Estimation of Polymer Translocation through Nano-Membrane Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu Polymers (Basel) Article In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by P(x, t), as a macromolecular chain of lengthiness equal to x, to be able to pass by the nanopore in escape period t, was optimized. The longest-lasting likely escape time found with this model is indicated to be t(p) = 330 μs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature. MDPI 2022-05-20 /pmc/articles/PMC9147610/ /pubmed/35631973 http://dx.doi.org/10.3390/polym14102090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu Time Estimation of Polymer Translocation through Nano-Membrane |
title | Time Estimation of Polymer Translocation through Nano-Membrane |
title_full | Time Estimation of Polymer Translocation through Nano-Membrane |
title_fullStr | Time Estimation of Polymer Translocation through Nano-Membrane |
title_full_unstemmed | Time Estimation of Polymer Translocation through Nano-Membrane |
title_short | Time Estimation of Polymer Translocation through Nano-Membrane |
title_sort | time estimation of polymer translocation through nano-membrane |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147610/ https://www.ncbi.nlm.nih.gov/pubmed/35631973 http://dx.doi.org/10.3390/polym14102090 |
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