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Time Estimation of Polymer Translocation through Nano-Membrane

In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary name...

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Autores principales: Paun, Maria-Alexandra, Paun, Vladimir-Alexandru, Paun, Viorel-Puiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147610/
https://www.ncbi.nlm.nih.gov/pubmed/35631973
http://dx.doi.org/10.3390/polym14102090
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author Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_facet Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_sort Paun, Maria-Alexandra
collection PubMed
description In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by P(x, t), as a macromolecular chain of lengthiness equal to x, to be able to pass by the nanopore in escape period t, was optimized. The longest-lasting likely escape time found with this model is indicated to be t(p) = 330 μs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature.
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spelling pubmed-91476102022-05-29 Time Estimation of Polymer Translocation through Nano-Membrane Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu Polymers (Basel) Article In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by P(x, t), as a macromolecular chain of lengthiness equal to x, to be able to pass by the nanopore in escape period t, was optimized. The longest-lasting likely escape time found with this model is indicated to be t(p) = 330 μs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature. MDPI 2022-05-20 /pmc/articles/PMC9147610/ /pubmed/35631973 http://dx.doi.org/10.3390/polym14102090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
Time Estimation of Polymer Translocation through Nano-Membrane
title Time Estimation of Polymer Translocation through Nano-Membrane
title_full Time Estimation of Polymer Translocation through Nano-Membrane
title_fullStr Time Estimation of Polymer Translocation through Nano-Membrane
title_full_unstemmed Time Estimation of Polymer Translocation through Nano-Membrane
title_short Time Estimation of Polymer Translocation through Nano-Membrane
title_sort time estimation of polymer translocation through nano-membrane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147610/
https://www.ncbi.nlm.nih.gov/pubmed/35631973
http://dx.doi.org/10.3390/polym14102090
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