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Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis

Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were a...

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Autores principales: Ramos-Martínez, Antonio, Pintos-Pascual, Ilduara, Guinea, Jesús, Gutiérrez-Villanueva, Andrea, Gutiérrez-Abreu, Edith, Díaz-García, Judith, Asensio, Ángel, Iranzo, Reyes, Sánchez-Romero, Isabel, Muñoz-Algarra, María, Moreno-Torres, Víctor, Calderón-Parra, Jorge, Múñez, Elena, Fernández-Cruz, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147669/
https://www.ncbi.nlm.nih.gov/pubmed/35628707
http://dx.doi.org/10.3390/jof8050451
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author Ramos-Martínez, Antonio
Pintos-Pascual, Ilduara
Guinea, Jesús
Gutiérrez-Villanueva, Andrea
Gutiérrez-Abreu, Edith
Díaz-García, Judith
Asensio, Ángel
Iranzo, Reyes
Sánchez-Romero, Isabel
Muñoz-Algarra, María
Moreno-Torres, Víctor
Calderón-Parra, Jorge
Múñez, Elena
Fernández-Cruz, Ana
author_facet Ramos-Martínez, Antonio
Pintos-Pascual, Ilduara
Guinea, Jesús
Gutiérrez-Villanueva, Andrea
Gutiérrez-Abreu, Edith
Díaz-García, Judith
Asensio, Ángel
Iranzo, Reyes
Sánchez-Romero, Isabel
Muñoz-Algarra, María
Moreno-Torres, Víctor
Calderón-Parra, Jorge
Múñez, Elena
Fernández-Cruz, Ana
author_sort Ramos-Martínez, Antonio
collection PubMed
description Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were assessed using the EUCAST E.Def 7.3.2 broth dilution method. Fluconazole-resistant C. parapsilosis isolates (FRCP) were studied for sequencing of the ERG11 gene. The incidence of candidemia and C. parapsilosis bloodstream infection increased significantly in the pandemic period (p = 0.021). ICU admission, mechanical ventilation, parenteral nutrition and corticosteroids administration were more frequent in patients with candidemia who had been admitted due to COVID-19. Fifteen cases of FRCP fungemia were detected. The first case was recorded 10 months before the pandemic in a patient transferred from another hospital. The incidence of FRCP in patients admitted for COVID-19 was 1.34 and 0.16 in all other patients (p < 0.001). ICU admission, previous Candida spp. colonization, arterial catheter use, parenteral nutrition and renal function replacement therapy were more frequent in patients with candidemia due to FRCP. All FRCP isolates showed the Y132F mutation. In conclusion, the incidence of candidemia experienced an increase during the COVID-19 pandemic and FRCP fungemia was more frequent in patients admitted due to COVID-19.
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spelling pubmed-91476692022-05-29 Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis Ramos-Martínez, Antonio Pintos-Pascual, Ilduara Guinea, Jesús Gutiérrez-Villanueva, Andrea Gutiérrez-Abreu, Edith Díaz-García, Judith Asensio, Ángel Iranzo, Reyes Sánchez-Romero, Isabel Muñoz-Algarra, María Moreno-Torres, Víctor Calderón-Parra, Jorge Múñez, Elena Fernández-Cruz, Ana J Fungi (Basel) Article Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were assessed using the EUCAST E.Def 7.3.2 broth dilution method. Fluconazole-resistant C. parapsilosis isolates (FRCP) were studied for sequencing of the ERG11 gene. The incidence of candidemia and C. parapsilosis bloodstream infection increased significantly in the pandemic period (p = 0.021). ICU admission, mechanical ventilation, parenteral nutrition and corticosteroids administration were more frequent in patients with candidemia who had been admitted due to COVID-19. Fifteen cases of FRCP fungemia were detected. The first case was recorded 10 months before the pandemic in a patient transferred from another hospital. The incidence of FRCP in patients admitted for COVID-19 was 1.34 and 0.16 in all other patients (p < 0.001). ICU admission, previous Candida spp. colonization, arterial catheter use, parenteral nutrition and renal function replacement therapy were more frequent in patients with candidemia due to FRCP. All FRCP isolates showed the Y132F mutation. In conclusion, the incidence of candidemia experienced an increase during the COVID-19 pandemic and FRCP fungemia was more frequent in patients admitted due to COVID-19. MDPI 2022-04-27 /pmc/articles/PMC9147669/ /pubmed/35628707 http://dx.doi.org/10.3390/jof8050451 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramos-Martínez, Antonio
Pintos-Pascual, Ilduara
Guinea, Jesús
Gutiérrez-Villanueva, Andrea
Gutiérrez-Abreu, Edith
Díaz-García, Judith
Asensio, Ángel
Iranzo, Reyes
Sánchez-Romero, Isabel
Muñoz-Algarra, María
Moreno-Torres, Víctor
Calderón-Parra, Jorge
Múñez, Elena
Fernández-Cruz, Ana
Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title_full Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title_fullStr Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title_full_unstemmed Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title_short Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
title_sort impact of the covid-19 pandemic on the clinical profile of candidemia and the incidence of fungemia due to fluconazole-resistant candida parapsilosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147669/
https://www.ncbi.nlm.nih.gov/pubmed/35628707
http://dx.doi.org/10.3390/jof8050451
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