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Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis
Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147669/ https://www.ncbi.nlm.nih.gov/pubmed/35628707 http://dx.doi.org/10.3390/jof8050451 |
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author | Ramos-Martínez, Antonio Pintos-Pascual, Ilduara Guinea, Jesús Gutiérrez-Villanueva, Andrea Gutiérrez-Abreu, Edith Díaz-García, Judith Asensio, Ángel Iranzo, Reyes Sánchez-Romero, Isabel Muñoz-Algarra, María Moreno-Torres, Víctor Calderón-Parra, Jorge Múñez, Elena Fernández-Cruz, Ana |
author_facet | Ramos-Martínez, Antonio Pintos-Pascual, Ilduara Guinea, Jesús Gutiérrez-Villanueva, Andrea Gutiérrez-Abreu, Edith Díaz-García, Judith Asensio, Ángel Iranzo, Reyes Sánchez-Romero, Isabel Muñoz-Algarra, María Moreno-Torres, Víctor Calderón-Parra, Jorge Múñez, Elena Fernández-Cruz, Ana |
author_sort | Ramos-Martínez, Antonio |
collection | PubMed |
description | Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were assessed using the EUCAST E.Def 7.3.2 broth dilution method. Fluconazole-resistant C. parapsilosis isolates (FRCP) were studied for sequencing of the ERG11 gene. The incidence of candidemia and C. parapsilosis bloodstream infection increased significantly in the pandemic period (p = 0.021). ICU admission, mechanical ventilation, parenteral nutrition and corticosteroids administration were more frequent in patients with candidemia who had been admitted due to COVID-19. Fifteen cases of FRCP fungemia were detected. The first case was recorded 10 months before the pandemic in a patient transferred from another hospital. The incidence of FRCP in patients admitted for COVID-19 was 1.34 and 0.16 in all other patients (p < 0.001). ICU admission, previous Candida spp. colonization, arterial catheter use, parenteral nutrition and renal function replacement therapy were more frequent in patients with candidemia due to FRCP. All FRCP isolates showed the Y132F mutation. In conclusion, the incidence of candidemia experienced an increase during the COVID-19 pandemic and FRCP fungemia was more frequent in patients admitted due to COVID-19. |
format | Online Article Text |
id | pubmed-9147669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91476692022-05-29 Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis Ramos-Martínez, Antonio Pintos-Pascual, Ilduara Guinea, Jesús Gutiérrez-Villanueva, Andrea Gutiérrez-Abreu, Edith Díaz-García, Judith Asensio, Ángel Iranzo, Reyes Sánchez-Romero, Isabel Muñoz-Algarra, María Moreno-Torres, Víctor Calderón-Parra, Jorge Múñez, Elena Fernández-Cruz, Ana J Fungi (Basel) Article Severely ill COVID-19 patients are at high risk of nosocomial infections. The aim of the study was to describe the characteristics of candidemia during the pre-pandemic period (January 2019–February 2020) compared to the pandemic period (March 2020–September 2021). Antifungal susceptibilities were assessed using the EUCAST E.Def 7.3.2 broth dilution method. Fluconazole-resistant C. parapsilosis isolates (FRCP) were studied for sequencing of the ERG11 gene. The incidence of candidemia and C. parapsilosis bloodstream infection increased significantly in the pandemic period (p = 0.021). ICU admission, mechanical ventilation, parenteral nutrition and corticosteroids administration were more frequent in patients with candidemia who had been admitted due to COVID-19. Fifteen cases of FRCP fungemia were detected. The first case was recorded 10 months before the pandemic in a patient transferred from another hospital. The incidence of FRCP in patients admitted for COVID-19 was 1.34 and 0.16 in all other patients (p < 0.001). ICU admission, previous Candida spp. colonization, arterial catheter use, parenteral nutrition and renal function replacement therapy were more frequent in patients with candidemia due to FRCP. All FRCP isolates showed the Y132F mutation. In conclusion, the incidence of candidemia experienced an increase during the COVID-19 pandemic and FRCP fungemia was more frequent in patients admitted due to COVID-19. MDPI 2022-04-27 /pmc/articles/PMC9147669/ /pubmed/35628707 http://dx.doi.org/10.3390/jof8050451 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ramos-Martínez, Antonio Pintos-Pascual, Ilduara Guinea, Jesús Gutiérrez-Villanueva, Andrea Gutiérrez-Abreu, Edith Díaz-García, Judith Asensio, Ángel Iranzo, Reyes Sánchez-Romero, Isabel Muñoz-Algarra, María Moreno-Torres, Víctor Calderón-Parra, Jorge Múñez, Elena Fernández-Cruz, Ana Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title | Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title_full | Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title_fullStr | Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title_full_unstemmed | Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title_short | Impact of the COVID-19 Pandemic on the Clinical Profile of Candidemia and the Incidence of Fungemia Due to Fluconazole-Resistant Candida parapsilosis |
title_sort | impact of the covid-19 pandemic on the clinical profile of candidemia and the incidence of fungemia due to fluconazole-resistant candida parapsilosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147669/ https://www.ncbi.nlm.nih.gov/pubmed/35628707 http://dx.doi.org/10.3390/jof8050451 |
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