Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors

Hydroxamate, as a zinc-binding group (ZBG), prevails in the design of histone deacetylase 6(HDAC6) inhibitors due to its remarkable zinc-chelating capability. However, hydroxamate-associated genotoxicity and mutagenicity have limited the widespread application of corresponding HDAC6 inhibitors in th...

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Detalles Bibliográficos
Autores principales: Xu, Yangrong, Tang, Hangjun, Xu, Yijie, Guo, Jialin, Zhao, Xu, Meng, Qingguo, Xiao, Junhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147695/
https://www.ncbi.nlm.nih.gov/pubmed/35630812
http://dx.doi.org/10.3390/molecules27103335

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