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A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and my...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147731/ https://www.ncbi.nlm.nih.gov/pubmed/35632709 http://dx.doi.org/10.3390/v14050969 |
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author | de Lima Cavalcanti, Thaise Yasmine Vasconcelos Pereira, Mylena Ribeiro de Paula, Sergio Oliveira Franca, Rafael Freitas de Oliveira |
author_facet | de Lima Cavalcanti, Thaise Yasmine Vasconcelos Pereira, Mylena Ribeiro de Paula, Sergio Oliveira Franca, Rafael Freitas de Oliveira |
author_sort | de Lima Cavalcanti, Thaise Yasmine Vasconcelos |
collection | PubMed |
description | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain–Barré Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates. |
format | Online Article Text |
id | pubmed-9147731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91477312022-05-29 A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development de Lima Cavalcanti, Thaise Yasmine Vasconcelos Pereira, Mylena Ribeiro de Paula, Sergio Oliveira Franca, Rafael Freitas de Oliveira Viruses Review Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain–Barré Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates. MDPI 2022-05-05 /pmc/articles/PMC9147731/ /pubmed/35632709 http://dx.doi.org/10.3390/v14050969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Lima Cavalcanti, Thaise Yasmine Vasconcelos Pereira, Mylena Ribeiro de Paula, Sergio Oliveira Franca, Rafael Freitas de Oliveira A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title_full | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title_fullStr | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title_full_unstemmed | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title_short | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
title_sort | review on chikungunya virus epidemiology, pathogenesis and current vaccine development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147731/ https://www.ncbi.nlm.nih.gov/pubmed/35632709 http://dx.doi.org/10.3390/v14050969 |
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