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HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity

Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVEM), expressed on dendritic cells. Here, HVEM gene-deficient m...

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Autores principales: Gao, Yang, Cheng, Jishuai, Xu, Xingli, Li, Xueqi, Zhang, Jingjing, Ma, Danjing, Jiang, Guorun, Liao, Yun, Fan, Shengtao, Niu, Zhenye, Yue, Rong, Chang, Penglan, Zeng, Fengyuan, Duan, Suqin, Meng, Ziyan, Xu, Xiangxiong, Li, Xinghang, Li, Dandan, Yu, Li, Ping, Lifen, Zhao, Heng, Guo, Mingtian, Wang, Lichun, Wang, Yafang, Zhang, Ying, Li, Qihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147763/
https://www.ncbi.nlm.nih.gov/pubmed/35632787
http://dx.doi.org/10.3390/v14051046
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author Gao, Yang
Cheng, Jishuai
Xu, Xingli
Li, Xueqi
Zhang, Jingjing
Ma, Danjing
Jiang, Guorun
Liao, Yun
Fan, Shengtao
Niu, Zhenye
Yue, Rong
Chang, Penglan
Zeng, Fengyuan
Duan, Suqin
Meng, Ziyan
Xu, Xiangxiong
Li, Xinghang
Li, Dandan
Yu, Li
Ping, Lifen
Zhao, Heng
Guo, Mingtian
Wang, Lichun
Wang, Yafang
Zhang, Ying
Li, Qihan
author_facet Gao, Yang
Cheng, Jishuai
Xu, Xingli
Li, Xueqi
Zhang, Jingjing
Ma, Danjing
Jiang, Guorun
Liao, Yun
Fan, Shengtao
Niu, Zhenye
Yue, Rong
Chang, Penglan
Zeng, Fengyuan
Duan, Suqin
Meng, Ziyan
Xu, Xiangxiong
Li, Xinghang
Li, Dandan
Yu, Li
Ping, Lifen
Zhao, Heng
Guo, Mingtian
Wang, Lichun
Wang, Yafang
Zhang, Ying
Li, Qihan
author_sort Gao, Yang
collection PubMed
description Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVEM), expressed on dendritic cells. Here, HVEM gene-deficient mice were used to investigate the immunologic effect elicited by the HSV-1 infection of dendritic cells. Dendritic cells expressing the surface marker CD11c showed an abnormal biological phenotype, including the altered transcription of various immune signaling molecules and inflammatory factors associated with innate immunity after viral replication. Furthermore, the viral infection of dendritic cells interfered with dendritic cell function in the lymph nodes, where these cells normally play roles in activating the T-cell response. Additionally, the mild clinicopathological manifestations observed during the acute phase of HSV-1 infection were associated with viral replication in dendritic cells.
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spelling pubmed-91477632022-05-29 HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity Gao, Yang Cheng, Jishuai Xu, Xingli Li, Xueqi Zhang, Jingjing Ma, Danjing Jiang, Guorun Liao, Yun Fan, Shengtao Niu, Zhenye Yue, Rong Chang, Penglan Zeng, Fengyuan Duan, Suqin Meng, Ziyan Xu, Xiangxiong Li, Xinghang Li, Dandan Yu, Li Ping, Lifen Zhao, Heng Guo, Mingtian Wang, Lichun Wang, Yafang Zhang, Ying Li, Qihan Viruses Article Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVEM), expressed on dendritic cells. Here, HVEM gene-deficient mice were used to investigate the immunologic effect elicited by the HSV-1 infection of dendritic cells. Dendritic cells expressing the surface marker CD11c showed an abnormal biological phenotype, including the altered transcription of various immune signaling molecules and inflammatory factors associated with innate immunity after viral replication. Furthermore, the viral infection of dendritic cells interfered with dendritic cell function in the lymph nodes, where these cells normally play roles in activating the T-cell response. Additionally, the mild clinicopathological manifestations observed during the acute phase of HSV-1 infection were associated with viral replication in dendritic cells. MDPI 2022-05-14 /pmc/articles/PMC9147763/ /pubmed/35632787 http://dx.doi.org/10.3390/v14051046 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Yang
Cheng, Jishuai
Xu, Xingli
Li, Xueqi
Zhang, Jingjing
Ma, Danjing
Jiang, Guorun
Liao, Yun
Fan, Shengtao
Niu, Zhenye
Yue, Rong
Chang, Penglan
Zeng, Fengyuan
Duan, Suqin
Meng, Ziyan
Xu, Xiangxiong
Li, Xinghang
Li, Dandan
Yu, Li
Ping, Lifen
Zhao, Heng
Guo, Mingtian
Wang, Lichun
Wang, Yafang
Zhang, Ying
Li, Qihan
HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title_full HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title_fullStr HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title_full_unstemmed HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title_short HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
title_sort hsv-1 infection of epithelial dendritic cells is a critical strategy for interfering with antiviral immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147763/
https://www.ncbi.nlm.nih.gov/pubmed/35632787
http://dx.doi.org/10.3390/v14051046
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