Aptamer–Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemcitabine and improve its therapeutic efficacy, we sy...

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Detalles Bibliográficos
Autores principales: Qi, Jianjun, Zeng, Zihua, Chen, Zhenghu, Nipper, Cole, Liu, Xiaohui, Wan, Quanyuan, Chen, Jian, Tung, Ching-Hsuan, Zu, Youli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147807/
https://www.ncbi.nlm.nih.gov/pubmed/35631384
http://dx.doi.org/10.3390/ph15050558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147807/
https://www.ncbi.nlm.nih.gov/pubmed/35631384
http://dx.doi.org/10.3390/ph15050558

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