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Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review

Licorice is known as “Gan-Cao” in traditional Chinese Medicine (TCM), belonging to the genus Glycyrrhiza (Family: Fabaceae/Leguminosae). It has a long medicinal history and wide applications in China. Polysaccharides of licorice (LPs) are one of the key bioactive components. As herbal polysaccharide...

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Autores principales: Ain, Noor Ul, Wu, Shuye, Li, Xiang, Li, Duxin, Zhang, Zhenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147829/
https://www.ncbi.nlm.nih.gov/pubmed/35629680
http://dx.doi.org/10.3390/ma15103654
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author Ain, Noor Ul
Wu, Shuye
Li, Xiang
Li, Duxin
Zhang, Zhenqing
author_facet Ain, Noor Ul
Wu, Shuye
Li, Xiang
Li, Duxin
Zhang, Zhenqing
author_sort Ain, Noor Ul
collection PubMed
description Licorice is known as “Gan-Cao” in traditional Chinese Medicine (TCM), belonging to the genus Glycyrrhiza (Family: Fabaceae/Leguminosae). It has a long medicinal history and wide applications in China. Polysaccharides of licorice (LPs) are one of the key bioactive components. As herbal polysaccharides attracted increasing interest in the past several decades, their extraction, isolation, structural characterization, pharmacological activities, and medicinal application have been explored extensively. It is worth heeding that the method of extraction and purification effects LPs, apart from specie and origin specificity. This review evaluates the method of extraction and purification and demonstrates its performance in gaining specific composition and its structure-activity relationship, which might lead the readers to a fresh horizon for developing advanced treatment strategies. It is recently reported that the conformation of LPs plays a vital role as biopolymers, such as selenized modification, microencapsulation, nanocomposite, liposome formulation, drug/hydrogel combinations, biosensor device, and synergistic effect with a vaccine. In addition, LPs showed a good thermodynamics profile, as these properties enable them to interact with additional supramolecular interaction by chemical modifications or copolymerization. Functional polymers that are responsive to various external stimuli, such as physical, chemical, and biological signals, are a promising study topic. Thus, LPs are emerging as a new biomaterial that can enhance intended formulation along exerting its inherent medicinal effects. It is hoped that this review will provide a basis for the utilization and further developments of licorice polysaccharides in the vast medium.
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spelling pubmed-91478292022-05-29 Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review Ain, Noor Ul Wu, Shuye Li, Xiang Li, Duxin Zhang, Zhenqing Materials (Basel) Review Licorice is known as “Gan-Cao” in traditional Chinese Medicine (TCM), belonging to the genus Glycyrrhiza (Family: Fabaceae/Leguminosae). It has a long medicinal history and wide applications in China. Polysaccharides of licorice (LPs) are one of the key bioactive components. As herbal polysaccharides attracted increasing interest in the past several decades, their extraction, isolation, structural characterization, pharmacological activities, and medicinal application have been explored extensively. It is worth heeding that the method of extraction and purification effects LPs, apart from specie and origin specificity. This review evaluates the method of extraction and purification and demonstrates its performance in gaining specific composition and its structure-activity relationship, which might lead the readers to a fresh horizon for developing advanced treatment strategies. It is recently reported that the conformation of LPs plays a vital role as biopolymers, such as selenized modification, microencapsulation, nanocomposite, liposome formulation, drug/hydrogel combinations, biosensor device, and synergistic effect with a vaccine. In addition, LPs showed a good thermodynamics profile, as these properties enable them to interact with additional supramolecular interaction by chemical modifications or copolymerization. Functional polymers that are responsive to various external stimuli, such as physical, chemical, and biological signals, are a promising study topic. Thus, LPs are emerging as a new biomaterial that can enhance intended formulation along exerting its inherent medicinal effects. It is hoped that this review will provide a basis for the utilization and further developments of licorice polysaccharides in the vast medium. MDPI 2022-05-20 /pmc/articles/PMC9147829/ /pubmed/35629680 http://dx.doi.org/10.3390/ma15103654 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ain, Noor Ul
Wu, Shuye
Li, Xiang
Li, Duxin
Zhang, Zhenqing
Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title_full Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title_fullStr Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title_full_unstemmed Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title_short Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review
title_sort isolation, characterization, pharmacology and biopolymer applications of licorice polysaccharides: review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147829/
https://www.ncbi.nlm.nih.gov/pubmed/35629680
http://dx.doi.org/10.3390/ma15103654
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