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Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia

A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection...

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Autores principales: Quenon, Camille, Hennebelle, Thierry, Butaud, Jean-François, Ho, Raimana, Samaillie, Jennifer, Neut, Christel, Lehartel, Tamatoa, Rivière, Céline, Siah, Ali, Bonneau, Natacha, Sahpaz, Sevser, Anthérieu, Sébastien, Lebegue, Nicolas, Raharivelomanana, Phila, Roumy, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147835/
https://www.ncbi.nlm.nih.gov/pubmed/35629400
http://dx.doi.org/10.3390/life12050733
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author Quenon, Camille
Hennebelle, Thierry
Butaud, Jean-François
Ho, Raimana
Samaillie, Jennifer
Neut, Christel
Lehartel, Tamatoa
Rivière, Céline
Siah, Ali
Bonneau, Natacha
Sahpaz, Sevser
Anthérieu, Sébastien
Lebegue, Nicolas
Raharivelomanana, Phila
Roumy, Vincent
author_facet Quenon, Camille
Hennebelle, Thierry
Butaud, Jean-François
Ho, Raimana
Samaillie, Jennifer
Neut, Christel
Lehartel, Tamatoa
Rivière, Céline
Siah, Ali
Bonneau, Natacha
Sahpaz, Sevser
Anthérieu, Sébastien
Lebegue, Nicolas
Raharivelomanana, Phila
Roumy, Vincent
author_sort Quenon, Camille
collection PubMed
description A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases.
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spelling pubmed-91478352022-05-29 Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia Quenon, Camille Hennebelle, Thierry Butaud, Jean-François Ho, Raimana Samaillie, Jennifer Neut, Christel Lehartel, Tamatoa Rivière, Céline Siah, Ali Bonneau, Natacha Sahpaz, Sevser Anthérieu, Sébastien Lebegue, Nicolas Raharivelomanana, Phila Roumy, Vincent Life (Basel) Article A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases. MDPI 2022-05-14 /pmc/articles/PMC9147835/ /pubmed/35629400 http://dx.doi.org/10.3390/life12050733 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quenon, Camille
Hennebelle, Thierry
Butaud, Jean-François
Ho, Raimana
Samaillie, Jennifer
Neut, Christel
Lehartel, Tamatoa
Rivière, Céline
Siah, Ali
Bonneau, Natacha
Sahpaz, Sevser
Anthérieu, Sébastien
Lebegue, Nicolas
Raharivelomanana, Phila
Roumy, Vincent
Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title_full Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title_fullStr Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title_full_unstemmed Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title_short Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
title_sort antimicrobial properties of compounds isolated from syzygium malaccense (l.) merr. and l.m. perry and medicinal plants used in french polynesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147835/
https://www.ncbi.nlm.nih.gov/pubmed/35629400
http://dx.doi.org/10.3390/life12050733
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