Cargando…
Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia
A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147835/ https://www.ncbi.nlm.nih.gov/pubmed/35629400 http://dx.doi.org/10.3390/life12050733 |
_version_ | 1784716904773976064 |
---|---|
author | Quenon, Camille Hennebelle, Thierry Butaud, Jean-François Ho, Raimana Samaillie, Jennifer Neut, Christel Lehartel, Tamatoa Rivière, Céline Siah, Ali Bonneau, Natacha Sahpaz, Sevser Anthérieu, Sébastien Lebegue, Nicolas Raharivelomanana, Phila Roumy, Vincent |
author_facet | Quenon, Camille Hennebelle, Thierry Butaud, Jean-François Ho, Raimana Samaillie, Jennifer Neut, Christel Lehartel, Tamatoa Rivière, Céline Siah, Ali Bonneau, Natacha Sahpaz, Sevser Anthérieu, Sébastien Lebegue, Nicolas Raharivelomanana, Phila Roumy, Vincent |
author_sort | Quenon, Camille |
collection | PubMed |
description | A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases. |
format | Online Article Text |
id | pubmed-9147835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91478352022-05-29 Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia Quenon, Camille Hennebelle, Thierry Butaud, Jean-François Ho, Raimana Samaillie, Jennifer Neut, Christel Lehartel, Tamatoa Rivière, Céline Siah, Ali Bonneau, Natacha Sahpaz, Sevser Anthérieu, Sébastien Lebegue, Nicolas Raharivelomanana, Phila Roumy, Vincent Life (Basel) Article A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases. MDPI 2022-05-14 /pmc/articles/PMC9147835/ /pubmed/35629400 http://dx.doi.org/10.3390/life12050733 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Quenon, Camille Hennebelle, Thierry Butaud, Jean-François Ho, Raimana Samaillie, Jennifer Neut, Christel Lehartel, Tamatoa Rivière, Céline Siah, Ali Bonneau, Natacha Sahpaz, Sevser Anthérieu, Sébastien Lebegue, Nicolas Raharivelomanana, Phila Roumy, Vincent Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title | Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title_full | Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title_fullStr | Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title_full_unstemmed | Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title_short | Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia |
title_sort | antimicrobial properties of compounds isolated from syzygium malaccense (l.) merr. and l.m. perry and medicinal plants used in french polynesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147835/ https://www.ncbi.nlm.nih.gov/pubmed/35629400 http://dx.doi.org/10.3390/life12050733 |
work_keys_str_mv | AT quenoncamille antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT hennebellethierry antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT butaudjeanfrancois antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT horaimana antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT samailliejennifer antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT neutchristel antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT leharteltamatoa antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT riviereceline antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT siahali antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT bonneaunatacha antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT sahpazsevser antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT antherieusebastien antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT lebeguenicolas antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT raharivelomananaphila antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia AT roumyvincent antimicrobialpropertiesofcompoundsisolatedfromsyzygiummalaccenselmerrandlmperryandmedicinalplantsusedinfrenchpolynesia |