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Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations

Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent stud...

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Autores principales: Barbosa, Raquel de Melo, Leite, Aliana Monteiro, García-Villén, Fátima, Sánchez-Espejo, Rita, Cerezo, Pilar, Viseras, César, Faccendini, Angela, Sandri, Giuseppina, Raffin, Fernanda Nervo, Moura, Túlio Flávio Accioly de Lima e
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147908/
https://www.ncbi.nlm.nih.gov/pubmed/35631653
http://dx.doi.org/10.3390/pharmaceutics14051067
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author Barbosa, Raquel de Melo
Leite, Aliana Monteiro
García-Villén, Fátima
Sánchez-Espejo, Rita
Cerezo, Pilar
Viseras, César
Faccendini, Angela
Sandri, Giuseppina
Raffin, Fernanda Nervo
Moura, Túlio Flávio Accioly de Lima e
author_facet Barbosa, Raquel de Melo
Leite, Aliana Monteiro
García-Villén, Fátima
Sánchez-Espejo, Rita
Cerezo, Pilar
Viseras, César
Faccendini, Angela
Sandri, Giuseppina
Raffin, Fernanda Nervo
Moura, Túlio Flávio Accioly de Lima e
author_sort Barbosa, Raquel de Melo
collection PubMed
description Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method, using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology, hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural changes compatible with the amorphization of the material. Rheological assays highlighted a typical pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size diameters, and PDIs were similar, preset spherical and monodisperse structures (≈200 nm; <0.3), without significant change up to sixty days. The ZP values differed from each other, becoming higher with increasing AO concentration. XEDS spectra and elemental X-ray maps show peaks of lipids (organic components, C and O) and inorganic components O, Mg, and Si. All samples showed cell viability above 60%. The results indicated a stable, biocompatible hybrid system that can be an alternative for topical application.
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spelling pubmed-91479082022-05-29 Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations Barbosa, Raquel de Melo Leite, Aliana Monteiro García-Villén, Fátima Sánchez-Espejo, Rita Cerezo, Pilar Viseras, César Faccendini, Angela Sandri, Giuseppina Raffin, Fernanda Nervo Moura, Túlio Flávio Accioly de Lima e Pharmaceutics Article Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method, using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology, hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural changes compatible with the amorphization of the material. Rheological assays highlighted a typical pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size diameters, and PDIs were similar, preset spherical and monodisperse structures (≈200 nm; <0.3), without significant change up to sixty days. The ZP values differed from each other, becoming higher with increasing AO concentration. XEDS spectra and elemental X-ray maps show peaks of lipids (organic components, C and O) and inorganic components O, Mg, and Si. All samples showed cell viability above 60%. The results indicated a stable, biocompatible hybrid system that can be an alternative for topical application. MDPI 2022-05-17 /pmc/articles/PMC9147908/ /pubmed/35631653 http://dx.doi.org/10.3390/pharmaceutics14051067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barbosa, Raquel de Melo
Leite, Aliana Monteiro
García-Villén, Fátima
Sánchez-Espejo, Rita
Cerezo, Pilar
Viseras, César
Faccendini, Angela
Sandri, Giuseppina
Raffin, Fernanda Nervo
Moura, Túlio Flávio Accioly de Lima e
Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title_full Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title_fullStr Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title_full_unstemmed Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title_short Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations
title_sort hybrid lipid/clay carrier systems containing annatto oil for topical formulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147908/
https://www.ncbi.nlm.nih.gov/pubmed/35631653
http://dx.doi.org/10.3390/pharmaceutics14051067
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