Cargando…
Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue d...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147957/ https://www.ncbi.nlm.nih.gov/pubmed/35629301 http://dx.doi.org/10.3390/life12050633 |
_version_ | 1784716934980304896 |
---|---|
author | Artemyeva, Marina S. Vasileva, Ludmila B. Ma, Yi Kondratov, Kirill A. Fedorov, Anton V. Kostareva, Anna A. Lapshina, Sofia E. Anopova, Anna D. Likhonosov, Nikolai P. Neymark, Alexander E. Babenko, Alina Yu. Shlyakhto, Evgeny V. |
author_facet | Artemyeva, Marina S. Vasileva, Ludmila B. Ma, Yi Kondratov, Kirill A. Fedorov, Anton V. Kostareva, Anna A. Lapshina, Sofia E. Anopova, Anna D. Likhonosov, Nikolai P. Neymark, Alexander E. Babenko, Alina Yu. Shlyakhto, Evgeny V. |
author_sort | Artemyeva, Marina S. |
collection | PubMed |
description | Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery. The study includes control subjects, patients with obesity and patients with obesity accompanied by impaired carbohydrate metabolism (ICM). Quantitative analysis of lncRNA H19 levels has been performed using qPCR in plasma and subcutaneous (SAT) and visceral adipose tissue (VAT). Patients with obesity without ICM have higher levels of lncRNA H19 in VAT compared to SAT, and higher levels of lncRNA H19 in SAT compared to SAT of control individuals. One year after the intervention, levels of lncRNA H19 decreased in SAT of patients with obesity without ICM. The preoperative level of lncRNA H19 in VAT demonstrates a positive correlation with excess weight loss and a negative correlation with initial BMI. In conclusion, ICM affects expression of lncRNA H19 in SAT of patients with obesity. The preoperative level of lncRNA H19 in VAT can be used to predict excess weight loss in patients with obesity after bariatric surgery. |
format | Online Article Text |
id | pubmed-9147957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91479572022-05-29 Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery Artemyeva, Marina S. Vasileva, Ludmila B. Ma, Yi Kondratov, Kirill A. Fedorov, Anton V. Kostareva, Anna A. Lapshina, Sofia E. Anopova, Anna D. Likhonosov, Nikolai P. Neymark, Alexander E. Babenko, Alina Yu. Shlyakhto, Evgeny V. Life (Basel) Article Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery. The study includes control subjects, patients with obesity and patients with obesity accompanied by impaired carbohydrate metabolism (ICM). Quantitative analysis of lncRNA H19 levels has been performed using qPCR in plasma and subcutaneous (SAT) and visceral adipose tissue (VAT). Patients with obesity without ICM have higher levels of lncRNA H19 in VAT compared to SAT, and higher levels of lncRNA H19 in SAT compared to SAT of control individuals. One year after the intervention, levels of lncRNA H19 decreased in SAT of patients with obesity without ICM. The preoperative level of lncRNA H19 in VAT demonstrates a positive correlation with excess weight loss and a negative correlation with initial BMI. In conclusion, ICM affects expression of lncRNA H19 in SAT of patients with obesity. The preoperative level of lncRNA H19 in VAT can be used to predict excess weight loss in patients with obesity after bariatric surgery. MDPI 2022-04-25 /pmc/articles/PMC9147957/ /pubmed/35629301 http://dx.doi.org/10.3390/life12050633 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Artemyeva, Marina S. Vasileva, Ludmila B. Ma, Yi Kondratov, Kirill A. Fedorov, Anton V. Kostareva, Anna A. Lapshina, Sofia E. Anopova, Anna D. Likhonosov, Nikolai P. Neymark, Alexander E. Babenko, Alina Yu. Shlyakhto, Evgeny V. Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title | Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title_full | Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title_fullStr | Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title_full_unstemmed | Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title_short | Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery |
title_sort | relationship between the levels of lncrna h19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147957/ https://www.ncbi.nlm.nih.gov/pubmed/35629301 http://dx.doi.org/10.3390/life12050633 |
work_keys_str_mv | AT artemyevamarinas relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT vasilevaludmilab relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT mayi relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT kondratovkirilla relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT fedorovantonv relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT kostarevaannaa relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT lapshinasofiae relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT anopovaannad relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT likhonosovnikolaip relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT neymarkalexandere relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT babenkoalinayu relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery AT shlyakhtoevgenyv relationshipbetweenthelevelsoflncrnah19inplasmaanddifferentadiposetissuedepotswithpatientsresponsetobariatricsurgery |