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Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery

Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue d...

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Autores principales: Artemyeva, Marina S., Vasileva, Ludmila B., Ma, Yi, Kondratov, Kirill A., Fedorov, Anton V., Kostareva, Anna A., Lapshina, Sofia E., Anopova, Anna D., Likhonosov, Nikolai P., Neymark, Alexander E., Babenko, Alina Yu., Shlyakhto, Evgeny V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147957/
https://www.ncbi.nlm.nih.gov/pubmed/35629301
http://dx.doi.org/10.3390/life12050633
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author Artemyeva, Marina S.
Vasileva, Ludmila B.
Ma, Yi
Kondratov, Kirill A.
Fedorov, Anton V.
Kostareva, Anna A.
Lapshina, Sofia E.
Anopova, Anna D.
Likhonosov, Nikolai P.
Neymark, Alexander E.
Babenko, Alina Yu.
Shlyakhto, Evgeny V.
author_facet Artemyeva, Marina S.
Vasileva, Ludmila B.
Ma, Yi
Kondratov, Kirill A.
Fedorov, Anton V.
Kostareva, Anna A.
Lapshina, Sofia E.
Anopova, Anna D.
Likhonosov, Nikolai P.
Neymark, Alexander E.
Babenko, Alina Yu.
Shlyakhto, Evgeny V.
author_sort Artemyeva, Marina S.
collection PubMed
description Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery. The study includes control subjects, patients with obesity and patients with obesity accompanied by impaired carbohydrate metabolism (ICM). Quantitative analysis of lncRNA H19 levels has been performed using qPCR in plasma and subcutaneous (SAT) and visceral adipose tissue (VAT). Patients with obesity without ICM have higher levels of lncRNA H19 in VAT compared to SAT, and higher levels of lncRNA H19 in SAT compared to SAT of control individuals. One year after the intervention, levels of lncRNA H19 decreased in SAT of patients with obesity without ICM. The preoperative level of lncRNA H19 in VAT demonstrates a positive correlation with excess weight loss and a negative correlation with initial BMI. In conclusion, ICM affects expression of lncRNA H19 in SAT of patients with obesity. The preoperative level of lncRNA H19 in VAT can be used to predict excess weight loss in patients with obesity after bariatric surgery.
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spelling pubmed-91479572022-05-29 Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery Artemyeva, Marina S. Vasileva, Ludmila B. Ma, Yi Kondratov, Kirill A. Fedorov, Anton V. Kostareva, Anna A. Lapshina, Sofia E. Anopova, Anna D. Likhonosov, Nikolai P. Neymark, Alexander E. Babenko, Alina Yu. Shlyakhto, Evgeny V. Life (Basel) Article Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery. The study includes control subjects, patients with obesity and patients with obesity accompanied by impaired carbohydrate metabolism (ICM). Quantitative analysis of lncRNA H19 levels has been performed using qPCR in plasma and subcutaneous (SAT) and visceral adipose tissue (VAT). Patients with obesity without ICM have higher levels of lncRNA H19 in VAT compared to SAT, and higher levels of lncRNA H19 in SAT compared to SAT of control individuals. One year after the intervention, levels of lncRNA H19 decreased in SAT of patients with obesity without ICM. The preoperative level of lncRNA H19 in VAT demonstrates a positive correlation with excess weight loss and a negative correlation with initial BMI. In conclusion, ICM affects expression of lncRNA H19 in SAT of patients with obesity. The preoperative level of lncRNA H19 in VAT can be used to predict excess weight loss in patients with obesity after bariatric surgery. MDPI 2022-04-25 /pmc/articles/PMC9147957/ /pubmed/35629301 http://dx.doi.org/10.3390/life12050633 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Artemyeva, Marina S.
Vasileva, Ludmila B.
Ma, Yi
Kondratov, Kirill A.
Fedorov, Anton V.
Kostareva, Anna A.
Lapshina, Sofia E.
Anopova, Anna D.
Likhonosov, Nikolai P.
Neymark, Alexander E.
Babenko, Alina Yu.
Shlyakhto, Evgeny V.
Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title_full Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title_fullStr Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title_full_unstemmed Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title_short Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
title_sort relationship between the levels of lncrna h19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147957/
https://www.ncbi.nlm.nih.gov/pubmed/35629301
http://dx.doi.org/10.3390/life12050633
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