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The Microbiome as Part of the Contemporary View of Tuberculosis Disease

The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest h...

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Detalles Bibliográficos
Autores principales: Barbosa-Amezcua, Martín, Galeana-Cadena, David, Alvarado-Peña, Néstor, Silva-Herzog, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147979/
https://www.ncbi.nlm.nih.gov/pubmed/35631105
http://dx.doi.org/10.3390/pathogens11050584
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author Barbosa-Amezcua, Martín
Galeana-Cadena, David
Alvarado-Peña, Néstor
Silva-Herzog, Eugenia
author_facet Barbosa-Amezcua, Martín
Galeana-Cadena, David
Alvarado-Peña, Néstor
Silva-Herzog, Eugenia
author_sort Barbosa-Amezcua, Martín
collection PubMed
description The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Mycobacterium tuberculosis Complex. Even today, during the COVID-19 pandemic, it remains one of the principal causes of morbidity and mortality worldwide. Tuberculosis disease manifests itself as a dynamic spectrum that ranges from asymptomatic latent infection to life-threatening active disease. The review aims to provide an overview of the microbiome in the tuberculosis setting, both in patients’ and animal models. We discuss the relevance of the microbiome and its dysbiosis, and how, probably through its interaction with the immune system, it is a significant factor in tuberculosis’s susceptibility, establishment, and severity.
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spelling pubmed-91479792022-05-29 The Microbiome as Part of the Contemporary View of Tuberculosis Disease Barbosa-Amezcua, Martín Galeana-Cadena, David Alvarado-Peña, Néstor Silva-Herzog, Eugenia Pathogens Review The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Mycobacterium tuberculosis Complex. Even today, during the COVID-19 pandemic, it remains one of the principal causes of morbidity and mortality worldwide. Tuberculosis disease manifests itself as a dynamic spectrum that ranges from asymptomatic latent infection to life-threatening active disease. The review aims to provide an overview of the microbiome in the tuberculosis setting, both in patients’ and animal models. We discuss the relevance of the microbiome and its dysbiosis, and how, probably through its interaction with the immune system, it is a significant factor in tuberculosis’s susceptibility, establishment, and severity. MDPI 2022-05-16 /pmc/articles/PMC9147979/ /pubmed/35631105 http://dx.doi.org/10.3390/pathogens11050584 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barbosa-Amezcua, Martín
Galeana-Cadena, David
Alvarado-Peña, Néstor
Silva-Herzog, Eugenia
The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title_full The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title_fullStr The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title_full_unstemmed The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title_short The Microbiome as Part of the Contemporary View of Tuberculosis Disease
title_sort microbiome as part of the contemporary view of tuberculosis disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147979/
https://www.ncbi.nlm.nih.gov/pubmed/35631105
http://dx.doi.org/10.3390/pathogens11050584
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