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The Microbiome as Part of the Contemporary View of Tuberculosis Disease
The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147979/ https://www.ncbi.nlm.nih.gov/pubmed/35631105 http://dx.doi.org/10.3390/pathogens11050584 |
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author | Barbosa-Amezcua, Martín Galeana-Cadena, David Alvarado-Peña, Néstor Silva-Herzog, Eugenia |
author_facet | Barbosa-Amezcua, Martín Galeana-Cadena, David Alvarado-Peña, Néstor Silva-Herzog, Eugenia |
author_sort | Barbosa-Amezcua, Martín |
collection | PubMed |
description | The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Mycobacterium tuberculosis Complex. Even today, during the COVID-19 pandemic, it remains one of the principal causes of morbidity and mortality worldwide. Tuberculosis disease manifests itself as a dynamic spectrum that ranges from asymptomatic latent infection to life-threatening active disease. The review aims to provide an overview of the microbiome in the tuberculosis setting, both in patients’ and animal models. We discuss the relevance of the microbiome and its dysbiosis, and how, probably through its interaction with the immune system, it is a significant factor in tuberculosis’s susceptibility, establishment, and severity. |
format | Online Article Text |
id | pubmed-9147979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91479792022-05-29 The Microbiome as Part of the Contemporary View of Tuberculosis Disease Barbosa-Amezcua, Martín Galeana-Cadena, David Alvarado-Peña, Néstor Silva-Herzog, Eugenia Pathogens Review The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Mycobacterium tuberculosis Complex. Even today, during the COVID-19 pandemic, it remains one of the principal causes of morbidity and mortality worldwide. Tuberculosis disease manifests itself as a dynamic spectrum that ranges from asymptomatic latent infection to life-threatening active disease. The review aims to provide an overview of the microbiome in the tuberculosis setting, both in patients’ and animal models. We discuss the relevance of the microbiome and its dysbiosis, and how, probably through its interaction with the immune system, it is a significant factor in tuberculosis’s susceptibility, establishment, and severity. MDPI 2022-05-16 /pmc/articles/PMC9147979/ /pubmed/35631105 http://dx.doi.org/10.3390/pathogens11050584 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barbosa-Amezcua, Martín Galeana-Cadena, David Alvarado-Peña, Néstor Silva-Herzog, Eugenia The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title | The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title_full | The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title_fullStr | The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title_full_unstemmed | The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title_short | The Microbiome as Part of the Contemporary View of Tuberculosis Disease |
title_sort | microbiome as part of the contemporary view of tuberculosis disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147979/ https://www.ncbi.nlm.nih.gov/pubmed/35631105 http://dx.doi.org/10.3390/pathogens11050584 |
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