Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

It is well known that Semaphorin 4D (Sema4D) inhibits IGF-1-mediated osteogenesis by binding with PlexinB1 expressed on osteoblasts. However, its elevated level in the gingival crevice fluid of periodontitis patients and the broader scope of its activities in the context of potential upregulation of...

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Detalles Bibliográficos
Autores principales: Ishii, Takenobu, Ruiz-Torruella, Montserrat, Yamamoto, Kenta, Yamaguchi, Tsuguno, Heidari, Alireza, Pierrelus, Roodelyne, Leon, Elizabeth, Shindo, Satoru, Rawas-Qalaji, Mohamad, Pastore, Maria Rita, Ikeda, Atsushi, Nakamura, Shin, Mawardi, Hani, Kandalam, Umadevi, Hardigan, Patrick, Witek, Lukasz, Coelho, Paulo G., Kawai, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148012/
https://www.ncbi.nlm.nih.gov/pubmed/35628440
http://dx.doi.org/10.3390/ijms23105630

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