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Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury

Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a number of factors including the mechanism and se...

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Autores principales: Adler, Michael, Pellett, Sabine, Sharma, Shashi K., Lebeda, Frank J., Dembek, Zygmunt F., Mahan, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148055/
https://www.ncbi.nlm.nih.gov/pubmed/35630331
http://dx.doi.org/10.3390/microorganisms10050886
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author Adler, Michael
Pellett, Sabine
Sharma, Shashi K.
Lebeda, Frank J.
Dembek, Zygmunt F.
Mahan, Mark A.
author_facet Adler, Michael
Pellett, Sabine
Sharma, Shashi K.
Lebeda, Frank J.
Dembek, Zygmunt F.
Mahan, Mark A.
author_sort Adler, Michael
collection PubMed
description Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a number of factors including the mechanism and severity of the trauma, the distance from injury to the reinnervation target, connective tissue sheath integrity, and delay between injury and treatment. Even though modern surgical procedures have greatly improved the success rate, many peripheral nerve injuries still culminate in persistent neuropathic pain and incomplete functional recovery. Recent studies in animals suggest that botulinum neurotoxin A (BoNT/A) can accelerate nerve regeneration and improve functional recovery after injury to peripheral nerves. Possible mechanisms of BoNT/A action include activation or proliferation of support cells (Schwann cells, mast cells, and macrophages), increased angiogenesis, and improvement of blood flow to regenerating nerves.
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spelling pubmed-91480552022-05-29 Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury Adler, Michael Pellett, Sabine Sharma, Shashi K. Lebeda, Frank J. Dembek, Zygmunt F. Mahan, Mark A. Microorganisms Review Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a number of factors including the mechanism and severity of the trauma, the distance from injury to the reinnervation target, connective tissue sheath integrity, and delay between injury and treatment. Even though modern surgical procedures have greatly improved the success rate, many peripheral nerve injuries still culminate in persistent neuropathic pain and incomplete functional recovery. Recent studies in animals suggest that botulinum neurotoxin A (BoNT/A) can accelerate nerve regeneration and improve functional recovery after injury to peripheral nerves. Possible mechanisms of BoNT/A action include activation or proliferation of support cells (Schwann cells, mast cells, and macrophages), increased angiogenesis, and improvement of blood flow to regenerating nerves. MDPI 2022-04-24 /pmc/articles/PMC9148055/ /pubmed/35630331 http://dx.doi.org/10.3390/microorganisms10050886 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Adler, Michael
Pellett, Sabine
Sharma, Shashi K.
Lebeda, Frank J.
Dembek, Zygmunt F.
Mahan, Mark A.
Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title_full Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title_fullStr Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title_full_unstemmed Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title_short Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
title_sort preclinical evidence for the role of botulinum neurotoxin a (bont/a) in the treatment of peripheral nerve injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148055/
https://www.ncbi.nlm.nih.gov/pubmed/35630331
http://dx.doi.org/10.3390/microorganisms10050886
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