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The Association between Serum Testosterone and Hyperuricemia in Males
Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148059/ https://www.ncbi.nlm.nih.gov/pubmed/35628869 http://dx.doi.org/10.3390/jcm11102743 |
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author | Tsai, Meng-Ko Hung, Kuang-Chen Liao, Chun-Cheng Pan, Lung-Fa Hung, Chia-Lien Yang, Deng-Ho |
author_facet | Tsai, Meng-Ko Hung, Kuang-Chen Liao, Chun-Cheng Pan, Lung-Fa Hung, Chia-Lien Yang, Deng-Ho |
author_sort | Tsai, Meng-Ko |
collection | PubMed |
description | Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measured on enrolment. The primary endpoints were SU levels ≥ 7 mg/dL and ≥9 mg/dL. On enrolment, participants had a mean age of 45.6 years and mean total testosterone and SU levels of 510 ng/dL and 6.6 mg/dL, respectively. The mean total testosterone levels were 533 and 470 ng/dL in patients with SU levels < 7 mg/dL and ≥7 mg/dL, respectively (p < 0.001); and 515 and 425 ng/dL in patients with SU levels < 9 mg/dL and ≥9 mg/dL, respectively (p < 0.001). After adjusting for age, body mass index, creatinine, serum lipid, fasting blood glucose, systolic blood pressure, and diastolic blood pressure, low testosterone level (<400 ng/dL) was significantly associated with an SU level ≥ 7 mg/dL (hazard ratio: 1.182, 95% confidence interval: 1.005–1.39) and ≥9 mg/dL (hazard ratio: 1.905, 95% confidence interval: 1.239–2.928). In men, a low testosterone level may be associated with an increased risk of hyperuricemia. |
format | Online Article Text |
id | pubmed-9148059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91480592022-05-29 The Association between Serum Testosterone and Hyperuricemia in Males Tsai, Meng-Ko Hung, Kuang-Chen Liao, Chun-Cheng Pan, Lung-Fa Hung, Chia-Lien Yang, Deng-Ho J Clin Med Article Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measured on enrolment. The primary endpoints were SU levels ≥ 7 mg/dL and ≥9 mg/dL. On enrolment, participants had a mean age of 45.6 years and mean total testosterone and SU levels of 510 ng/dL and 6.6 mg/dL, respectively. The mean total testosterone levels were 533 and 470 ng/dL in patients with SU levels < 7 mg/dL and ≥7 mg/dL, respectively (p < 0.001); and 515 and 425 ng/dL in patients with SU levels < 9 mg/dL and ≥9 mg/dL, respectively (p < 0.001). After adjusting for age, body mass index, creatinine, serum lipid, fasting blood glucose, systolic blood pressure, and diastolic blood pressure, low testosterone level (<400 ng/dL) was significantly associated with an SU level ≥ 7 mg/dL (hazard ratio: 1.182, 95% confidence interval: 1.005–1.39) and ≥9 mg/dL (hazard ratio: 1.905, 95% confidence interval: 1.239–2.928). In men, a low testosterone level may be associated with an increased risk of hyperuricemia. MDPI 2022-05-12 /pmc/articles/PMC9148059/ /pubmed/35628869 http://dx.doi.org/10.3390/jcm11102743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tsai, Meng-Ko Hung, Kuang-Chen Liao, Chun-Cheng Pan, Lung-Fa Hung, Chia-Lien Yang, Deng-Ho The Association between Serum Testosterone and Hyperuricemia in Males |
title | The Association between Serum Testosterone and Hyperuricemia in Males |
title_full | The Association between Serum Testosterone and Hyperuricemia in Males |
title_fullStr | The Association between Serum Testosterone and Hyperuricemia in Males |
title_full_unstemmed | The Association between Serum Testosterone and Hyperuricemia in Males |
title_short | The Association between Serum Testosterone and Hyperuricemia in Males |
title_sort | association between serum testosterone and hyperuricemia in males |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148059/ https://www.ncbi.nlm.nih.gov/pubmed/35628869 http://dx.doi.org/10.3390/jcm11102743 |
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