Cargando…

The Association between Serum Testosterone and Hyperuricemia in Males

Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Meng-Ko, Hung, Kuang-Chen, Liao, Chun-Cheng, Pan, Lung-Fa, Hung, Chia-Lien, Yang, Deng-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148059/
https://www.ncbi.nlm.nih.gov/pubmed/35628869
http://dx.doi.org/10.3390/jcm11102743
_version_ 1784716959892373504
author Tsai, Meng-Ko
Hung, Kuang-Chen
Liao, Chun-Cheng
Pan, Lung-Fa
Hung, Chia-Lien
Yang, Deng-Ho
author_facet Tsai, Meng-Ko
Hung, Kuang-Chen
Liao, Chun-Cheng
Pan, Lung-Fa
Hung, Chia-Lien
Yang, Deng-Ho
author_sort Tsai, Meng-Ko
collection PubMed
description Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measured on enrolment. The primary endpoints were SU levels ≥ 7 mg/dL and ≥9 mg/dL. On enrolment, participants had a mean age of 45.6 years and mean total testosterone and SU levels of 510 ng/dL and 6.6 mg/dL, respectively. The mean total testosterone levels were 533 and 470 ng/dL in patients with SU levels < 7 mg/dL and ≥7 mg/dL, respectively (p < 0.001); and 515 and 425 ng/dL in patients with SU levels < 9 mg/dL and ≥9 mg/dL, respectively (p < 0.001). After adjusting for age, body mass index, creatinine, serum lipid, fasting blood glucose, systolic blood pressure, and diastolic blood pressure, low testosterone level (<400 ng/dL) was significantly associated with an SU level ≥ 7 mg/dL (hazard ratio: 1.182, 95% confidence interval: 1.005–1.39) and ≥9 mg/dL (hazard ratio: 1.905, 95% confidence interval: 1.239–2.928). In men, a low testosterone level may be associated with an increased risk of hyperuricemia.
format Online
Article
Text
id pubmed-9148059
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91480592022-05-29 The Association between Serum Testosterone and Hyperuricemia in Males Tsai, Meng-Ko Hung, Kuang-Chen Liao, Chun-Cheng Pan, Lung-Fa Hung, Chia-Lien Yang, Deng-Ho J Clin Med Article Gout is a common systemic inflammatory disease with a male predominance. This study aimed to determine the relationship between serum total testosterone level and hyperuricemia. Data on 1899 men, collected from 2007 to 2017, were included in the analysis. Serum testosterone and urate (SU) were measured on enrolment. The primary endpoints were SU levels ≥ 7 mg/dL and ≥9 mg/dL. On enrolment, participants had a mean age of 45.6 years and mean total testosterone and SU levels of 510 ng/dL and 6.6 mg/dL, respectively. The mean total testosterone levels were 533 and 470 ng/dL in patients with SU levels < 7 mg/dL and ≥7 mg/dL, respectively (p < 0.001); and 515 and 425 ng/dL in patients with SU levels < 9 mg/dL and ≥9 mg/dL, respectively (p < 0.001). After adjusting for age, body mass index, creatinine, serum lipid, fasting blood glucose, systolic blood pressure, and diastolic blood pressure, low testosterone level (<400 ng/dL) was significantly associated with an SU level ≥ 7 mg/dL (hazard ratio: 1.182, 95% confidence interval: 1.005–1.39) and ≥9 mg/dL (hazard ratio: 1.905, 95% confidence interval: 1.239–2.928). In men, a low testosterone level may be associated with an increased risk of hyperuricemia. MDPI 2022-05-12 /pmc/articles/PMC9148059/ /pubmed/35628869 http://dx.doi.org/10.3390/jcm11102743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsai, Meng-Ko
Hung, Kuang-Chen
Liao, Chun-Cheng
Pan, Lung-Fa
Hung, Chia-Lien
Yang, Deng-Ho
The Association between Serum Testosterone and Hyperuricemia in Males
title The Association between Serum Testosterone and Hyperuricemia in Males
title_full The Association between Serum Testosterone and Hyperuricemia in Males
title_fullStr The Association between Serum Testosterone and Hyperuricemia in Males
title_full_unstemmed The Association between Serum Testosterone and Hyperuricemia in Males
title_short The Association between Serum Testosterone and Hyperuricemia in Males
title_sort association between serum testosterone and hyperuricemia in males
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148059/
https://www.ncbi.nlm.nih.gov/pubmed/35628869
http://dx.doi.org/10.3390/jcm11102743
work_keys_str_mv AT tsaimengko theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT hungkuangchen theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT liaochuncheng theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT panlungfa theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT hungchialien theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT yangdengho theassociationbetweenserumtestosteroneandhyperuricemiainmales
AT tsaimengko associationbetweenserumtestosteroneandhyperuricemiainmales
AT hungkuangchen associationbetweenserumtestosteroneandhyperuricemiainmales
AT liaochuncheng associationbetweenserumtestosteroneandhyperuricemiainmales
AT panlungfa associationbetweenserumtestosteroneandhyperuricemiainmales
AT hungchialien associationbetweenserumtestosteroneandhyperuricemiainmales
AT yangdengho associationbetweenserumtestosteroneandhyperuricemiainmales