Cargando…

A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species

Little is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC...

Descripción completa

Detalles Bibliográficos
Autores principales: Won, Eun Jeong, Jang, Hyun Hee, Park, Hansoo, Kim, Seong Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148078/
https://www.ncbi.nlm.nih.gov/pubmed/35630309
http://dx.doi.org/10.3390/microorganisms10050864
_version_ 1784716964467310592
author Won, Eun Jeong
Jang, Hyun Hee
Park, Hansoo
Kim, Seong Jin
author_facet Won, Eun Jeong
Jang, Hyun Hee
Park, Hansoo
Kim, Seong Jin
author_sort Won, Eun Jeong
collection PubMed
description Little is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC) were included in this study. The microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. The scalp microbiome was more diverse in AA patients compared to HC, but not significantly different according to the severity of AA. Nevertheless, the higher proportion of Corynebacterium species and the lower proportion of Staphylococcus caprae among the Staphylococcus species were noticed in severe AA patients compared to HC or mild AA. The higher ratio of Cutibacterium species to S. caprae was noticed in severe AA. We highlight the potential predictive role of scalp microbiome profiling to a worse prognosis of patients with alopecia areata.
format Online
Article
Text
id pubmed-9148078
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91480782022-05-29 A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species Won, Eun Jeong Jang, Hyun Hee Park, Hansoo Kim, Seong Jin Microorganisms Brief Report Little is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC) were included in this study. The microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. The scalp microbiome was more diverse in AA patients compared to HC, but not significantly different according to the severity of AA. Nevertheless, the higher proportion of Corynebacterium species and the lower proportion of Staphylococcus caprae among the Staphylococcus species were noticed in severe AA patients compared to HC or mild AA. The higher ratio of Cutibacterium species to S. caprae was noticed in severe AA. We highlight the potential predictive role of scalp microbiome profiling to a worse prognosis of patients with alopecia areata. MDPI 2022-04-21 /pmc/articles/PMC9148078/ /pubmed/35630309 http://dx.doi.org/10.3390/microorganisms10050864 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Won, Eun Jeong
Jang, Hyun Hee
Park, Hansoo
Kim, Seong Jin
A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title_full A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title_fullStr A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title_full_unstemmed A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title_short A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus caprae, Corynebacterium, and Cutibacterium Species
title_sort potential predictive role of the scalp microbiome profiling in patients with alopecia areata: staphylococcus caprae, corynebacterium, and cutibacterium species
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148078/
https://www.ncbi.nlm.nih.gov/pubmed/35630309
http://dx.doi.org/10.3390/microorganisms10050864
work_keys_str_mv AT woneunjeong apotentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT janghyunhee apotentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT parkhansoo apotentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT kimseongjin apotentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT woneunjeong potentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT janghyunhee potentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT parkhansoo potentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies
AT kimseongjin potentialpredictiveroleofthescalpmicrobiomeprofilinginpatientswithalopeciaareatastaphylococcuscapraecorynebacteriumandcutibacteriumspecies