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Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study

COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between...

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Autores principales: Yavuz, Serap Şimşek, Tunçer, Gülşah, Altuntaş-Aydın, Özlem, Aydın, Mehtap, Pehlivanoğlu, Filiz, Tok, Yeşim, Mese, Sevim, Gündüz, Alper, Güçlü, Ceyda Geyiktepe, Özdoğan, İklima, Hemiş-Aydın, Börçe, Soğuksu, Pınar, Benli, Aysun, Başaran, Seniha, Midilli, Kenan, Eraksoy, Haluk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148084/
https://www.ncbi.nlm.nih.gov/pubmed/35632489
http://dx.doi.org/10.3390/vaccines10050733
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author Yavuz, Serap Şimşek
Tunçer, Gülşah
Altuntaş-Aydın, Özlem
Aydın, Mehtap
Pehlivanoğlu, Filiz
Tok, Yeşim
Mese, Sevim
Gündüz, Alper
Güçlü, Ceyda Geyiktepe
Özdoğan, İklima
Hemiş-Aydın, Börçe
Soğuksu, Pınar
Benli, Aysun
Başaran, Seniha
Midilli, Kenan
Eraksoy, Haluk
author_facet Yavuz, Serap Şimşek
Tunçer, Gülşah
Altuntaş-Aydın, Özlem
Aydın, Mehtap
Pehlivanoğlu, Filiz
Tok, Yeşim
Mese, Sevim
Gündüz, Alper
Güçlü, Ceyda Geyiktepe
Özdoğan, İklima
Hemiş-Aydın, Börçe
Soğuksu, Pınar
Benli, Aysun
Başaran, Seniha
Midilli, Kenan
Eraksoy, Haluk
author_sort Yavuz, Serap Şimşek
collection PubMed
description COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fully vaccinated with Coronovac or not. All hospitalized COVID-19 patients who had at least one dose of Coronavac were included in the study. The oldest unvaccinated patients with comorbidities, who were hospitalized during the same period, were chosen as controls. All epidemiologic, clinical and laboratory data of the patients were recorded and compared between the fully vaccinated and unvaccinated individuals. There were 69 and 217 patients who had been either fully vaccinated with Coronavac or not, respectively. All breakthrough infections occurred in the first 3 months of vaccination. Fully vaccinated patients were older and had more comorbidities than unvaccinated patients. There were minor differences between the groups in symptoms, physical and laboratory findings, anti-spike IgG positivity rate and level, the severity of COVID-19, complications, and clinical improvement rate. The mortality rate of fully vaccinated patients was higher than the mortality rate in unvaccinated patients in univariate analysis, which was attributed to the fact that vaccinated patients were older and had more comorbidities. The severity and clinical outcomes of hospitalized patients with breakthrough COVID-19 after Coronavac vaccination were similar to those of unvaccinated patients. Our findings suggest that the immune response elicited by Coronovac could be insufficient to prevent COVID-19-related severe disease and death within 3 months of vaccination among elderly people with comorbidities.
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spelling pubmed-91480842022-05-29 Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study Yavuz, Serap Şimşek Tunçer, Gülşah Altuntaş-Aydın, Özlem Aydın, Mehtap Pehlivanoğlu, Filiz Tok, Yeşim Mese, Sevim Gündüz, Alper Güçlü, Ceyda Geyiktepe Özdoğan, İklima Hemiş-Aydın, Börçe Soğuksu, Pınar Benli, Aysun Başaran, Seniha Midilli, Kenan Eraksoy, Haluk Vaccines (Basel) Article COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fully vaccinated with Coronovac or not. All hospitalized COVID-19 patients who had at least one dose of Coronavac were included in the study. The oldest unvaccinated patients with comorbidities, who were hospitalized during the same period, were chosen as controls. All epidemiologic, clinical and laboratory data of the patients were recorded and compared between the fully vaccinated and unvaccinated individuals. There were 69 and 217 patients who had been either fully vaccinated with Coronavac or not, respectively. All breakthrough infections occurred in the first 3 months of vaccination. Fully vaccinated patients were older and had more comorbidities than unvaccinated patients. There were minor differences between the groups in symptoms, physical and laboratory findings, anti-spike IgG positivity rate and level, the severity of COVID-19, complications, and clinical improvement rate. The mortality rate of fully vaccinated patients was higher than the mortality rate in unvaccinated patients in univariate analysis, which was attributed to the fact that vaccinated patients were older and had more comorbidities. The severity and clinical outcomes of hospitalized patients with breakthrough COVID-19 after Coronavac vaccination were similar to those of unvaccinated patients. Our findings suggest that the immune response elicited by Coronovac could be insufficient to prevent COVID-19-related severe disease and death within 3 months of vaccination among elderly people with comorbidities. MDPI 2022-05-07 /pmc/articles/PMC9148084/ /pubmed/35632489 http://dx.doi.org/10.3390/vaccines10050733 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yavuz, Serap Şimşek
Tunçer, Gülşah
Altuntaş-Aydın, Özlem
Aydın, Mehtap
Pehlivanoğlu, Filiz
Tok, Yeşim
Mese, Sevim
Gündüz, Alper
Güçlü, Ceyda Geyiktepe
Özdoğan, İklima
Hemiş-Aydın, Börçe
Soğuksu, Pınar
Benli, Aysun
Başaran, Seniha
Midilli, Kenan
Eraksoy, Haluk
Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title_full Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title_fullStr Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title_full_unstemmed Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title_short Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
title_sort comparison of the clinical and laboratory findings and outcomes of hospitalized covid-19 patients who were either fully vaccinated with coronavac or not: an analytical, cross sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148084/
https://www.ncbi.nlm.nih.gov/pubmed/35632489
http://dx.doi.org/10.3390/vaccines10050733
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